SLX4 (SLX4 structure-specific endonuclease subunit)
symbol
SLX4
locus group
protein-coding gene
location
16p13.3
gene_family
Fanconi anemia, complementation groups|BTB (POZ) domain containing
alias symbol
KIAA1784|KIAA1987|FANCP
alias name
Fanconi anemia, complementation gr…
entrez id
84464
ensembl gene id
ENSG00000188827
ucsc gene id
uc002cvp.3
refseq accession
NM_032444
hgnc_id
HGNC:23845
approved reserved
2003-12-15
ChineseEnglish
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]
Protein Sequence
1MKLSVNEAQL GFYLGSLSHL SACPGIDPRS SEDQPESLKT
41GQMMDESDED FKELCASFFQ RVKKHGIKEV SGERKTQKAA
81
SNGTQIRSK LKRTKQTATK TKTLQGPAEK KPPSGSQAPR
121TKKQRVTKWQ ASEPAHSVNG EGGVLASAPD PPVLRETAQN
161T
QTGNQQEP SPNLSREKTR ENVPNSDSQP PPSCLTTAVP
201SPSKPRTAQL VLQRMQQFKR ADPERLRHAS EECSLEAARE
241EN
VPKDPQE EMMAGNVYGL GPPAPESDAA VALTLQQEFA
281RVGASAHDDS LEEKGLFFCQ ICQKNLSAMN VTRREQHVNR
321CLD
EAEKTL RPSVPQIPEC PICGKPFLTL KSRTSHLKQC
361AVKMEVGPQL LLQAVRLQTA QPEGSSSPPM FSFSDHSRGL
401KRRG
PTSKK EPRKRRKVDE APSEDLLVAM ALSRSEMEPG
441AAVPALRLES AFSERIRPEA ENKSRKKKPP VSPPLLLVQD
481SETTG
RQIE DRVALLLSEE VELSSTPPLP ASRILKEGWE
521RAGQCPPPPE RKQSFLWEGS ALTGAWAMED FYTARLVPPL
561VPQRPA
QGL MQEPVPPLVP PEHSELSERR SPALHGTPTA
601GCGSRGPSPS ASQREHQALQ DLVDLAREGL SASPWPGSGG
641LAGSEGT
AG LDVVPGGLPL TGFVVPSQDK HPDRGGRTLL
681SLGLLVADFG AMVNNPHLSD VQFQTDSGEV LYAHKFVLYA
721RCPLLIQY
V NNEGFSAVED GVLTQRVLLG DVSTEAARTF
761LHYLYTADTG LPPGLSSELS SLAHRFGVSE LVHLCEQVPI
801ATDSEGKPW
EEKEAENCES RAENFQELLR SMWADEEEEA
841ETLLKSKDHE EDQENVNEAE MEEIYEFAAT QRKLLQEERA
881AGAGEDADWL
EGGSPVSGQ LLAGVQVQKQ WDKVEEMEPL
921EPGRDEAATT WEKMGQCALP PPQGQHSGAR GAEAPEQEAP
961EEALGHSSCS S
PSRDCQAE RKEGSLPHSD DAGDYEQLFS
1001STQGEISEPS QITSEPEEQS GAVRERGLEV SHRLAPWQAS
1041PPHPCRFLLG PP
QGGSPRG SHHTSGSSLS TPRSRGGTSQ
1081VGSPTLLSPA VPSKQKRDRS ILTLSKEPGH QKGKERRSVL
1121ECRNKGVLMF PEK
SPSIDL TQSNPDHSSS RSQKSSSKLN
1161EEDEVILLLD SDEELELEQT KMKSISSDPL EEKKALEISP
1201RSCELFSIID VDAD
QEPSQ SPPRSEAVLQ QEDEGALPEN
1241RGSLGRRGAP WLFCDRESSP SEASTTDTSW LVPATPLASR
1281SRDCSSQTQI SSLRS
GLAV QAVTQHTPRA SVGNREGNEV
1321AQKFSVIRPQ TPPPQTPSSC LTPVSPGTSD GRRQGHRSPS
1361RPHPGGHPHS SPLAPH
PIS GDRAHFSRRF LKHSPPGPSF
1401LNQTPAGEVV EVGDSDDEQE VASHQANRSP PLDSDPPIPI
1441DDCCWHMEPL SPIPIDH
WN LERTGPLSTS SPSRRMNEAA
1481DSRDCRSPGL LDTTPIRGSC TTQRKLQEKS SGAGSLGNSR
1521PSFLNSALWD VWDGEEQR
P PETPPPAQMP SAGGAQKPEG
1561LETPKGANRK KNLPPKVPIT PMPQYSIMET PVLKKELDRF
1601GVRPLPKRQM VLKLKEIFQ
YTHQTLDSDS EDESQSSQPL
1641LQAPHCQTLA SQTYKPSRAG VHAQQEATTG PGAHRPKGPA
1681KTKGPRHQRK HHESITPPSR
SPTKEAPPG LNDDAQIPAS
1721QESVATSVDG SDSSLSSQSS SSCEFGAAFE SAGEEEGEGE
1761VSASQAAVQA ADTDEALRCY I
RSKPALYQ KVLLYQPFEL
1801RELQAELRQN GLRVSSRRLL DFLDTHCITF TTAATRREKL
1841QGRRRQPRGK KKVERN
Structure predicted by AlphaFold DB(UniProt: Q8IY92). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).
Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
TTCAGAAGAGTGCTCCCTC
59
CCAAGCCCATACACATTCC
59
TTCAGAAGAGTGCTCCCTC
59
CCAAGCCCATACACATTCC
59
GTGTGCTGTGAAGATGGAG
59
TCACTGAAGCTGAACATGG
58
AACTGGATAGGTTTGGAGTC
57
GGTGAGTGTACTGGAATATCTC
58
CTTCAGAAGAGTGCTCCCT
59
CAAGCCCATACACATTCCC
59
CTTCAGAAGAGTGCTCCCT
59
CAAGCCCATACACATTCCC
59
CTGTGAAGATGGAGGTTGG
58
ATCACTGAAGCTGAACATGG
58
AGAAGGAACTGGATAGGTTTGG
60
TGTACTGGAATATCTCCTTCAGC
60
TTCAGAAGAGTGCTCCCTC
59
CAAGCCCATACACATTCCC
59
CTGTGAAGATGGAGGTTGG
58
TCACTGAAGCTGAACATGG
58
Gene Ontology
Subcellular localization of SLX4 (and its protein):
- plasma membrane
- cytoplasm
- extracellular
- golgi
- vesicle
- cytoskeleton
- endoplasmic reticulum
- nucleus
- endosome
- lysosome
- mitochondrion
Gene Ontology (GO) terms for SLX4:
GO ID
Protein
Source DB
GO:0000724
Q8IY92 (UniProtKB)
IMP
GO:0000724
Q8IY92 (UniProtKB)
IMP
GO:0004520
Q8IY92 (UniProtKB)
TAS
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005515
Q8IY92 (UniProtKB)
IPI
GO:0005654
Q8IY92 (UniProtKB)
IDA
GO:0005654
Q8IY92 (UniProtKB)
TAS
GO:0005654
Q8IY92 (UniProtKB)
TAS
GO:0005654
Q8IY92 (UniProtKB)
TAS
GO:0005654
Q8IY92 (UniProtKB)
TAS
GO:0005737
Q8IY92 (UniProtKB)
IDA
GO:0006260
Q8IY92 (UniProtKB)
IEA
GO:0006281
Q8IY92 (UniProtKB)
IMP
GO:0006289
Q8IY92 (UniProtKB)
IMP
GO:0008047
Q8IY92 (UniProtKB)
IDA
GO:0010792
Q8IY92 (UniProtKB)
IMP
GO:0030054
Q8IY92 (UniProtKB)
IDA
GO:0033557
Q8IY92 (UniProtKB)
IDA
GO:0033557
Q8IY92 (UniProtKB)
IDA
GO:0033557
Q8IY92 (UniProtKB)
IDA
GO:0036297
Q8IY92 (UniProtKB)
TAS
GO:0043085
Q8IY92 (UniProtKB)
IEA
GO:0072429
Q8IY92 (UniProtKB)
IMP
GO:0090656
Q8IY92 (UniProtKB)
ISS
GO:1904431
Q8IY92 (UniProtKB)
ISS
GO:0000784
Q8IY92 (UniProtKB)
IDA
GO:0000790
Q8IY92 (UniProtKB)
IDA
GO:0048476
Q8IY92 (UniProtKB)
IDA
GO:0048476
Q8IY92 (UniProtKB)
IDA
GO:0048476
Q8IY92 (UniProtKB)
IDA
GO:0070522
Q8IY92 (UniProtKB)
IDA
GO:0070522
Q8IY92 (UniProtKB)
IDA
GO:0070522
Q8IY92 (UniProtKB)
IDA
GO:0008821
Q8IY92 (UniProtKB)
IDA
GO:0008821
Q8IY92 (UniProtKB)
IDA
GO:0008821
Q8IY92 (UniProtKB)
IDA
GO:0017108
Q8IY92 (UniProtKB)
IDA
GO:0017108
Q8IY92 (UniProtKB)
IDA
GO:0017108
Q8IY92 (UniProtKB)
IDA
GO:0048257
Q8IY92 (UniProtKB)
IDA
GO:0048257
Q8IY92 (UniProtKB)
IDA
String
BioGrid
IntAct
mentha
Loading…
| Interacting Gene | Interaction | Source/Score |
| Disease | Score | NofPmids | NofSnps | Source |
| Fanconi Anemia | 0.242171535 | 9 | 0 | BeFree_CTD_human_ORPHANET |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Breast Cancer, Familial | 0.000814326 | 3 | 0 | BeFree |
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