WTIP (WT1 interacting protein)

Gene Basic Information

Gene Basic Information

symbol
WTIP
locus group
protein-coding gene
location
19q13.11
gene_family
-
alias symbol
-
alias name
WT1-interacting protein
entrez id
126374
ensembl gene id
ENSG00000142279
ucsc gene id
uc002nvm.4
refseq accession
NM_001080436
hgnc_id
HGNC:20964
approved reserved
2005-02-11

Chromosome Location

Chromosome Location

19q13.11

Gene Summary

Gene Summary

WTIP（Wilms tumor 1-interacting protein）是一种与Wilms肿瘤抑制蛋白（WT1）相互作用的蛋白质，主要参与细胞骨架的调节和信号转导过程。WTIP在细胞黏附、细胞形态维持以及细胞迁移中发挥重要作用，尤其在肾脏发育过程中具有关键功能。它主要定位于细胞膜和细胞连接处，如紧密连接和黏着斑，通过与肌动蛋白细胞骨架结合来维持细胞结构的稳定性。WTIP还参与调控多个信号通路，包括Hippo信号通路，影响细胞增殖和器官大小控制。WTIP基因突变可能导致其功能异常，影响肾脏发育并增加Wilms肿瘤（一种儿童肾脏肿瘤）的风险，也可能与其他肾脏疾病或发育缺陷相关。WTIP过表达可能干扰正常的细胞黏附和迁移过程，导致细胞行为异常，而表达降低则可能削弱细胞骨架的稳定性，影响组织结构和功能。WTIP属于LIM结构域蛋白家族，该家族成员通常含有LIM结构域（一种锌指结构域），介导蛋白质之间的相互作用，参与细胞骨架组织、信号转导和基因表达调控等过程。LIM结构域蛋白家族的共性包括参与细胞形态维持、运动、分化以及发育过程的调控，许多成员在癌症和发育疾病中发挥作用。WTIP通过与WT1和其他伙伴蛋白的相互作用，在肾脏发育和疾病中扮演重要角色。

OMIM entry for WTIP     Wikipedia entry for WTIP

Gene Sequence

Gene Sequence

Nucleotide sequence of WTIP:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MQRSRAGADE AALLLAGLAL RELEPGCGSP GRGRRGPRPG
41PGDEAAPALG RRGKGSGGPE AGADGLSRGE RGPRRAAVPE
81 LSAQPAGSP RASLAGSDGG GGGGSARSSG ISLGYDQRHG
121SPRSGRSDPR PGPGPPSVGS ARSSVSSLGS RGSAGAYADF
161L PPGACPAP ARSPEPAGPA PFPLPALPLP PGREGGPSAA
201ERRLEALTRE LERALEARTA RDYFGICIKC GLGIYGAQQA
241CQ AMGSLYH TDCFTCDSCG RRLRGKAFYN VGEKVYCQED
281FLYSGFQQTA DKCSVCGHLI MEMILQALGK SYHPGCFRCS
321VCN ECLDGV PFTVDVENNI YCVRDYHTVF APKCASCARP
361ILPAQGCETT IRVVSMDRDY HVACYHCEDC GLQLSGEEGR
401RCYP LAGHL LCRRCHLRRL QPGPLPSPTV HVTEL
Structure predicted by AlphaFold DB(UniProt: A6NIX2). Color indicates pLDDT confidence (dark blue = high, yellow/orange = low).

Gene Variants

Gene Variants

SNP variants of WTIP:           Showing partial SNPs
rs1122110       rs1465433       rs2059147       rs2277979       rs2277980       rs2277981       rs2863315       rs2863316       rs2902629       rs2910403       rs2910414       rs2910415       rs2910416       rs2910417       rs2965282       rs2965283       rs3068689      

Gene Expression

Gene Expression

Tissue expression of WTIP:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
GGACTACTTCGGCATTTGC
59
AGTCAGTGTGATAAAGACTCCC
60
GACTACTTCGGCATTTGCA
59
CAGTCAGTGTGATAAAGACTCC
59
GACTACTTCGGCATTTGCA
59
GTCAGTGTGATAAAGACTCCC
58

Gene Ontology

Subcellular localization of WTIP (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for WTIP:

GO ID
Protein
Source DB
GO:0000932
A6NIX2 (UniProtKB)
IDA
GO:0001666
A6NIX2 (UniProtKB)
IDA
GO:0003714
A6NIX2 (UniProtKB)
IEA
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005515
A6NIX2 (UniProtKB)
IPI
GO:0005634
A6NIX2 (UniProtKB)
IEA
GO:0005912
A6NIX2 (UniProtKB)
IEA
GO:0006351
A6NIX2 (UniProtKB)
IEA
GO:0006355
A6NIX2 (UniProtKB)
IEA
GO:0007010
A6NIX2 (UniProtKB)
IMP
GO:0008270
A6NIX2 (UniProtKB)
IEA
GO:0022604
A6NIX2 (UniProtKB)
IMP
GO:0035195
A6NIX2 (UniProtKB)
IMP
GO:0035331
A6NIX2 (UniProtKB)
IDA
GO:1903507
A6NIX2 (UniProtKB)
IEA
GO:2000637
A6NIX2 (UniProtKB)
IMP
GO:0008270
K7EKM1 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating WTIP:     

Gene Interactions

Gene Interactions

BioGrid
mentha
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Penile hypospadias 0.000542884 2 0 BeFree
Hypospadias 0.000542884 2 0 BeFree
Nephroblastoma 0.000271442 1 0 BeFree

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