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INCENP

Gene name:inner centromere protein

...INCENP在多种肿瘤(如乳腺癌、结直肠癌)中过表达,与基因组不稳定性和不良预后相关。若INCENP表达降低,则会导致细胞分裂阻滞或异常退出有丝分裂,诱发细胞凋亡。此外,INCENP的异常表达还会影响其他CPC成员(如Survivin)的定...

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