样本量：10 物种：Homo sapiens, Homo sapiens 类型：transcription profiling by array 2026年1月1日

...BRCA1-associated protein-1 (BAP1) was introduced under the control of a TRE/PCMVmin promoter, in addition to the existin...

样本量：161 物种：Homo sapiens, Homo sapiens 类型：RNA-seq of coding RNA from single cel... 2024年4月3日

...BRCA1/2 carriers had a distinct gene expression signature indicative of potential immune exhaustion which was validated ...

样本量：39 物种：Mus musculus, Mus musculus 类型：RNA-seq of coding RNA 2023年9月14日

...BRCA1 and BRCA2 genes and this strong preclinical evidence prompted their clinical development in tumors with BRCA1/BRCA...

样本量：11 物种：Homo sapiens, Homo sapiens 类型：genotyping by array 2022年12月30日

...BRCA1 variants identified in WES were validated using Sanger sequencing. 1084 somatic mutations identified in whole exom...

样本量：80 物种：Homo sapiens, Homo sapiens 类型：genotyping by high throughput sequencing 2022年12月15日

...BRCA1/2 germinal mutations and Mismatch Repair (MMR) defects, using next generation sequencing approach on DNA from form...

样本量：4 物种：Mus musculus, Mus musculus 类型：ATAC-seq, Animal - High-throughput se... 2021年2月2日

...Brca1/p53 and wild-type mice. This data was used to show that the perturbation of Brca1/p53in luminal progenitors induce...

样本量：29 物种：Mus musculus, Mus musculus 类型：RNA-seq of coding RNA from single cel... 2021年2月2日

...BRCA1 driven triple negative breast cancer (TNBC) for example has been shown to arise from luminal progenitor cells1,2 y...

样本量：8 物种：Homo sapiens, Homo sapiens 类型：RNA-seq of coding RNA 2021年2月2日

...BRCA1 driven triple negative breast cancer (TNBC) for example has been shown to arise from luminal progenitor cells yet ...

样本量：6 物种：Homo sapiens, Homo sapiens 类型：microRNA profiling by array, Cell lin... 2020年4月21日

...BRCA1, NBS1, RAD50, and MRE11. Our results demonstrated that the PD-L1 inhibitor significantly decreased the expression ...

样本量：36 物种：Homo sapiens 类型：transcription profiling by array 2018年10月31日

...BRCA1-mutation carriers and 6 controls were cultured and irradiated with 10Gy. Additional 15 mutation carriers and 5 con...