...NF1 mutations and BRAF mutations. Furthermore, when we compared the epigenetic profile of our tumors with those availabl...
...NF1). NFs are benign nerve sheath tumors due to bi-allelic loss of NF1, encoding a negative regulator of Ras pathway, in...
...NF1 knockout) and performed RNAseq.
...NF1 and KMT2D mutations and a complex karyotype. Furthermore we demonstrated that spatial transcriptomics can identify t...
...NF1 knockout and NRAS G12D, that induce the RAS signalling pathway were made in TF1 cells. The NRAS G12D mutant was trea...
To identify possible novel targets for the treatment of plexiform neurofibroma formation through a synthetic lethal shRN...
...NF1 mutations) were present in 10 of 15 patients and overrepresented in the HGG group (3/5) compared to previously repor...
...Nf1-/-) and macrophages (Nf1+/+) from 1-month-old neurofibroma, (3) Schwann cells (Nf1-/-) and macrophages (Nf1+/+) fr...
...NF1 (NF1-M), Sprouty (SPRY-M) and PTEN (PTEN-M) in gliomas. Their signatures enabled robust clustering of adult diffuse ...
...NF1 gene. However, no clear genotype-phenotype correlations could be identified among the NF1 patients carrying NF1 intr...
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