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Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancre…

Mercanoglu(B),Schraps(N),Giannou(AD),Zhou(J)… Neoplasia 2026-07-31

...C1galt1c1), the obligate molecular chaperone for T-synthase (C1galt1), in a pancreas-specific Kras-driven mouse model. A...

Deletion of Core 1 β3GalT-specific molecular chaperone (Cosmc) in murine intest…

Ju(T),Wang(Y),Nishio(H),Kudelka(MR),Sun(X),W… J Biol Chem 2026-04-00

...C1GalT1C1) that encodes a key ER molecular chaperone required for formation of active T-synthase, a Golgi enzyme that mo...

CD276 immature glycosylation drives colorectal cancer aggressiveness and T cell…

Soares(J),Ferreira(D),Miranda(A),Gonçalves(M… Cell Commun Signal 2026-01-20

...C1GALT1C1 defined an immature O-glycosylation phenotype associated with poor prognosis. Glycomic profiling revealed Tn- ...

Akkermansia muciniphila-Derived N-Acetylspermidine Modulates the Localization o…

Yao(Y),Pei(Z),Dai(Y),Chen(Y),Chang(Z),Wang(H… Adv Sci (Weinh) 2025-10-00

...C1GALT1C1. Furthermore, N-acetylspermidine-induced α1,2-fucosylation enhancement facilitated the membrane localization o...

Identification of differentially expressed genes and associated immune cell typ…

Devar(J),Baichan(P),Mpangase(PT),Elebo(N),Ca… Sci Rep 2025-11-11

...C1GALT1C1 and termination of O-glycan biosynthesis, highlighting key mechanisms potentially involved in tumour progressi...

Age‑dependent and post‑intraventricular hemorrhage remodeling of the ependymal …

Iida(T),Mori(K),Tomita(H),Ohmura(K),Taguchi(… Fluids Barriers CNS 2025-11-07

...C1GALT1C1) were downregulated, whereas ST3GAL5 and plasma-membrane sialidase NEU3 were upregulated. Additionally, senesc...

Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-li…

Chang(Diana),Gao(Feng),Slavney(Andrea),Ma(Li… PLoS One 2015-07-29

...C1GALT1C1 exhibits sex-specific effect on disease risk in both IBDs. These and other X-linked genes that we associated w...

Activation of the interleukin-4/signal transducer and activator of transcriptio…

He(Liyu),Peng(Youming),Liu(Hong),Yin(Wenqing… Am J Nephrol 2014-06-12

...C1GALT1C1), core1β3GalT-specific molecular chaperone (Cosmc) and HIPK2 in tonsil components were examined by immunohisto...

Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice.

Fu(Jianxin),Wei(Bo),Wen(Tao),Johansson(Malin… J Clin Invest 2011-06-21

...C1GALT1C1, also known as Cosmc), which is essential for core 1 O-glycosylation, were found in Tn-positive epithelia. The...

The role of C1GALT1C1 in lipopolysaccharide-induced IgA1 aberrant O-glycosylati…

Xie(Lin-Shen),Qin(Wei),Fan(Jun-Ming),Huang(J… Clin Invest Med 2010-04-22

...C1GALT1C1 expression in patients with IgAN. Upregulation of C1GALT1C1 expression by 5-AZA could reverse the IgA1 aberran...

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