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Targeting MAD2L2-dependent translesion synthesis impairs DNA damage tolerance a…

Ayiku(PJ),Barda(N),Weiss(OE),Sherman(C),Litv… Front Cell Dev Biol None

...MAD2L2-Rev1 axis was further supported by reduced formation of MAD2L2-Rev1 complexes, as assessed by proximity ligation ...

A high-risk sepsis subtype identified by regulated cell death signatures and MA…

Luo(L),Cao(D),Liao(Z),Lin(C),Wang(A),Zeng(L)… Front Immunol 2026-00-00

...MAD2L2, TNF-α, and IL-1β protein expression, whereas MAD2L2 knockdown reduced these inflammatory proteins and decreased ...

Destabilization of pluripotency in the absence of Mad2l2.

Pirouz(Mehdi),Rahjouei(Ali),Shamsi(Farnaz),E… Cell Cycle 2016-02-25

...Mad2l2. In effect, the intricate balance necessary for pluripotency becomes perturbed in the absence of Mad2l2.

Association between cell cycle gene transcription and tumor size in oral squamo…

Diniz(Marina Gonçalves),Silva(Jeane de Fatim… Tumour Biol 2016-04-26

...MAD2L2, CCNG2, E2F4, NBN, CUL2, PCNA, TFDP1, KNTC1, and ATR. Ki-67 labeling index was similar in both tumor groups. Our ...

Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindl…

Bhat(Audesh),Wu(Zhaojia),Maher(Veronica M),M… Cell Cycle 2016-09-26

...Mad2L2 or Rev7. Apart from its role in Polζ-mediated translesion DNA synthesis and double-strand break repair, Rev7 is a...

Overlapping in short motif sequences for binding to human REV7 and MAD2 protein…

Hanafusa(Tomo),Habu(Toshiyuki),Tomida(Junya)… Genes Cells 2015-07-02

...MAD2L2, because its primary sequence shows 26% identity to that of hMAD2 that plays crucial roles in spindle assembly ch...

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end res…

Boersma(Vera),Moatti(Nathalie),Segura-Bayona… Nature 2015-06-29

...MAD2L2-depleted cells. Control of DNA repair by MAD2L2 is not limited to telomeres. MAD2L2 also accumulates and inhibits...

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Xu(Guotai),Chapman(J Ross),Brandsma(Inger),Y… Nature 2015-06-29

...MAD2L2) in mouse and human cell lines re-establishes CTIP-dependent end resection of DSBs in BRCA1-deficient cells, lead...

A functional screen identifies miRNAs that inhibit DNA repair and sensitize pro…

Hatano(Koji),Kumar(Binod),Zhang(Yonggang),Co… Nucleic Acids Res 2015-07-21

...MAD2L2, as well as WEE1 and XPC, where miR-744-3p directly targeted RAD23B. Knock-down of individual miR-890 targets by ...

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mamma…

Tomida(Junya),Takata(Kei-ichi),Lange(Sabine … Nucleic Acids Res 2015-05-01

...MAD2L2) is considered an accessory subunit. However, it has not been established that the role of REV7 in DNA damage tol...

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