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Rapid detection of exon 2-deleted AIMP2 mutation as a potential biomarker for l…

Jo(Seong-Min),Kim(Youngwook),Jeong(Young-Su)… Biosens Bioelectron 2013-10-21

...AIMP2 (AIMP2-DX2) mutation to a specific cancer. Here, we demonstrate the rapid and simple detection of the AIMP2-DX2 mu...

Lentivirus-AIMP2-DX2 shRNA suppresses cell proliferation by regulating Akt1 sig…

Hwang(Soon-Kyung),Chang(Seung-Hee),Minai-Teh… J Aerosol Med Pulm Drug Deliv 2013-11-26

...AIMP2 lacking exon 2 (shDX2) on lung tumorigenesis were studied. Lentiviral-based shDX2 was delivered into AIMP2(+/-) mi...

Citric acid cycle and the origin of MARS.

Eswarappa(Sandeepa M),Fox(Paul L) Trends Biochem Sci 2013-11-19

...AIMP2, and AIMP3. The evolutionary origin of the MARS is unclear, as is the significance of the inclusion of only nine o...

Selective regression of cancer cells expressing a splicing variant of AIMP2 thr…

Won(You-Sub),Lee(Seong-Wook) J Biotechnol 2012-08-01

AIMP2/p38 is a scaffolding protein critical for the assembly of the macromolecular tRNA synthetase complex. Moreover, AI...

Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell …

Chang(Seung-Hee),Chung(Youn-Sun),Hwang(Soon-… Mol Cells 2012-10-19

...AIMP2 lacking exon 2 (AIMP2-DX2) is expressed in different cancer cells. We previously studied the expression level of A...

Splicing variant of AIMP2 as an effective target against chemoresistant ovarian…

Choi(Jin Woo),Lee(Jeong-Won),Kim(Jun Ki),Jeo… J Mol Cell Biol 2012-11-09

...AIMP2-DX2, a splicing variant of tumor suppressor AIMP2, can be a therapeutic target to control CR EOC. AIMP2-DX2 was of...

Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase compl…

Kim(Sung Soo),Hur(Soo Young),Kim(Yoo Ri),Yoo… Tumori 2011-08-25

...AIMP2 and AIMP3 in nearly all of the cases (95-100%). However, the expression of AIMP1, AIMP2 and AIMP3 was significantl...

Novel regulation of parkin function through c-Abl-mediated tyrosine phosphoryla…

Imam(Syed Z),Zhou(Qing),Yamamoto(Ayako),Vale… J Neurosci 2011-02-04

...AIMP2 (aminoacyl tRNA synthetase complex-interacting multifunctional protein 2) (p38/JTV-1) and FBP-1.STI-571, a selecti...

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in respon…

Liu(Juhong),Chung(Hye-Jung),Vogt(Matthew),Ji… EMBO J 2011-05-05

...AIMP2, a structural subunit of a multi-aminoacyl-tRNA synthetase (ARS) complex, has also been reported to stabilize p53 ...

Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological …

Choi(Jin Woo),Kim(Dae Gyu),Lee(Al-Eum),Kim(H… PLoS Genet 2011-07-26

...AIMP2 promotes apoptosis through the protective interaction with p53. However, it was not demonstrated whether AIMP2 was...

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