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A novel role for Rad17 in homologous recombination.

Nishino(Katsuaki),Inoue(Eri),Takada(Shunya),… Genes Genet Syst 2009-03-30

...RAD17 double knockout (blm/rad17) cells using chicken DT40 cells. The blm/rad17 cells showed exaggerated growth defects ...

Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiqui…

Yang(Xiaohong H),Zou(Lee) Cell Cycle 2009-04-08

...Rad17, two other Chk1 regulators at stressed replication forks, are also implicated in PCNA ubiquitination. These findin...

ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damag…

Medhurst(Annette L),Warmerdam(Daniël O),Aker… J Cell Sci 2009-02-27

...Rad17-RFC, the Rad9-Rad1-Hus1 complex, TopBP1 and Claspin. Rad17 is required for loading of Rad9-Rad1-Hus1 (9-1-1) onto ...

Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase.

Navadgi-Patil(Vasundhara M),Burgers(Peter M) J Biol Chem 2009-02-12

...Rad17 (human Rad9-Hus1-Rad1: 9-1-1) is loaded around effector DNA and thereby activates Mec1 kinase. Dpb11 (Schizosaccha...

Functional identification of tumor-suppressor genes through an in vivo RNA inte…

Bric(Anka),Miething(Cornelius),Bialucha(Carl… Cancer Cell 2009-10-15

...Rad17, which acts as a haploinsufficient tumor suppressor that responds to oncogenic stress and whose loss is associated...

Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.

Zhang(Nianxiang),Kaur(Ramandeep),Akhter(Sham… EMBO Rep 2009-11-10

...Rad17) and Fanconi anaemia complementation group D2 protein (FancD2). In addition, we have mapped the ATR-binding region...

Ribonucleotide reductase regulation in response to genotoxic stress in Arabidop…

Roa(Hélène),Lang(Julien),Culligan(Kevin M),K… Plant Physiol 2009-11-23

...rad17 double mutant. In contrast, AtTSO2 transcription is only activated in response to double-strand breaks (BLM), and ...

Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells…

Padua(Maria B),Hansen(Peter J) J Cell Biochem 2009-12-03

...RAD17, BRCA1, BCCIP, KPNA2, RAD1). Also, rOvUS down-regulated the cell proliferation marker gene MKI67, which is absent ...

A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the…

Navadgi-Patil(Vasundhara M),Burgers(Peter M) DNA Repair (Amst) 2009-11-04

...Rad17-Mec3 in S. cerevisiae) executes two distinct checkpoint functions. In S. cerevisiae, DNA-bound 9-1-1 directly acti...

Sic1-induced DNA rereplication during meiosis.

Sawarynski(Kara E),Najor(Nicole A),Kepsel(An… Proc Natl Acad Sci U S A 2009-02-13

...RAD17 restored the original phenotype. Therefore, activation of the meiotic recombination checkpoint, which arrests meio...

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