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DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

Nitiss(J),Wang(J C) Proc Natl Acad Sci U S A 1988-11-21

...rad52 mutation. An analog of mAMSA), which is ineffective as an inhibitor of DNA topoisomerase II in mammalian cells, is...

Selection of in vivo deletions in Saccharomyces cerevisiae.

Bitoun(R),Zamir(A) J Bacteriol 1988-10-06

...RAD52 and rad52 strains. Chromosomal deletions, which occurred at a frequency of approximately 10(-8) per viable cell, w...

Spontaneous mitotic recombination in yeast: the hyper-recombinational rem1 muta…

Montelone(B A),Hoekstra(M F),Malone(R E) Genetics 1988-09-06

...rad52 have reduced levels of gene conversion but wild-type frequencies of crossing over. We have interpreted these obser...

Purification and characterization of an endo-exonuclease from Saccharomyces cer…

Chow(T Y),Resnick(M A) J Biol Chem 1988-01-29

...RAD52 gene, the greatly reduced amounts in rad52 mutants implicate the enzyme in repair and recombination processes in b...

Expression of the yeast UB14 gene increases in response to DNA-damaging agents …

Treger(J M),Heichman(K A),McEntee(K) Mol Cell Biol 1988-06-14

...rad52, and rad6 repair-deficient yeast strains. In high-density RAD+ cultures, the effect of alkylating agents on UB14 t...

Evidence for Drosophila P element transposase activity in mammalian cells and y…

Rio(D C),Barnes(G),Laski(F A),Rine(J),Rubin(… J Mol Biol 1988-06-29

...RAD52 gene, indicating that double-stranded DNA breaks are generated, presumably by transposase action.

An endo-exonuclease activity of yeast that requires a functional RAD52 gene.

Chow(T Y),Resnick(M A) Mol Gen Genet 1988-04-05

...rad52, at least 20% of total activity was precipitable. Extracts from logarithmically growing rad52 mutants, including a...

Repair of double-strand breaks in plasmid DNA in the yeast Saccharomyces cerevi…

Perera(J R),Glasunov(A V),Glaser(V M),Boreik… Mol Gen Genet 1988-12-21

...rad52, rad53, rad54 and rad57 suppress the repair of DSB in plasmid DNA. The kinetics of DSB repair in plasmid DNA are b...

Direction of chromosome rearrangements in Saccharomyces cerevisiae by use of hi…

Fasullo(M T),Davis(R W) Mol Cell Biol 1988-12-21

...RAD52+ and rad52 mutant strains. Translocations occurred in the RAD52+ genetic background and were characterized by orth...

Formation and stability of linear plasmids in a recombination deficient strain …

Zakian(V A),Blanton(H M),Dani(G M) Curr Genet 1988-07-12

...RAD52 gene. Moreover, linear plasmids bearing these modified ciliate termini are stably propagated in rad52- cells.

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