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Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquiti…

Ko(Han Seok),Lee(Yunjong),Shin(Joo-Ho),Karup… Proc Natl Acad Sci U S A 2010-11-02

...AIMP2) (p38/JTV-1) and fuse-binding protein 1 (FBP1), and cell death. STI-571, a c-Abl-family kinase inhibitor, prevents...

Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad…

Park(Sang Gyu),Choi(Eung-Chil),Kim(Sunghoon) IUBMB Life 2010-06-14

...AIMP2/p38, and AIMP3/p18). Although the structure and functional implications for this complex formation are not complet...

Chapter 1: The physiological role of lysyl tRNA synthetase in the immune system.

Nechushtan(Hovav),Kim(Sunghoon),Kay(Gillian)… Adv Immunol 2009-10-14

...AIMP2. Besides its role in translation it has been demonstrated that LysRS can act as a cytokine-like molecule, secreted...

AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation …

Choi(Jin Woo),Kim(Dae Gyu),Park(Min Chul),Um… J Cell Sci 2009-10-16

...AIMP2 also plays pivotal roles in the regulation of cell proliferation and death. Although AIMP2 was previously shown to...

Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susce…

Choi(Jin Woo),Um(Jung Yeon),Kundu(Joydeb Kum… Carcinogenesis 2009-09-15

...AIMP2 cells and whether AIMP2 would be critical in preventing tumorigenesis using different in vivo tumor models. Both t...

Autophagy-mediated clearance of aggresomes is not a universal phenomenon.

Wong(Esther S P),Tan(Jeanne M M),Soong(Wen-E… Hum Mol Genet 2008-09-15

...AIMP2 (p38)- or mutant desmin-expressing cells are apparently resistant to autophagic clearance. Notably, AIMP2 (p38)- a...

AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to geno…

Han(Jung Min),Park(Bum-Joon),Park(Sang Gyu),… Proc Natl Acad Sci U S A 2008-09-16

...AIMP2 increased resistance to DNA damage-induced apoptosis, and introduction of AIMP2 into AIMP2-deficient cells restore...

Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and …

Oh(Ah-Young),Jung(Youn Sang),Kim(Jiseon),Lee… Cancer Res 0000-00-00

...AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cance...

Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with…

Kim(Dae Gyu),Lee(Jin Young),Lee(Ji-Hyun),Cho… Cancer Res 0000-00-00

...AIMP2 on S156, a residue that is exposed on the embedded GST domain of AIMP2. We further found that phospho-AIMP2 dissoc...

AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulatin…

Yum(Min Kyu),Kang(Jong-Seol),Lee(Al-Eum),Jo(… Cancer Res 0000-00-00

...Aimp2 hemizygosity increased adenoma formation. Mechanistically, AIMP2 disrupted the interaction between AXIN and Dishev...

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