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Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effec…

Salvati(Erica),Leonetti(Carlo),Rizzo(Angela)… J Clin Invest 2008-04-02

...RAD17, and 53BP1. This was dependent on DNA repair enzyme ATR, correlated with delocalization of the protective telomeri...

Roles of Saccharomyces cerevisiae RAD17 and CHK1 checkpoint genes in the repair…

Bracesco(Nelson),Candreva(Ema C),Keszenman(D… Radiat Environ Biophys 2008-02-06

...rad17Delta/rad17Delta, and an isogenic wild-type strain were exposed to the radiomimetic agent bleomycin (BLM). DNA doub...

Downregulation of RAD17 in head and neck cancer.

Zhao(Ming),Begum(Shahnaz),Ha(Patrick K),West… Head Neck 2008-03-28

...RAD17 protein in primary tumor tissue (0/12), while there was strong expression of hRAD17 protein in normal oral mucosal...

Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but …

Guervilly(Jean-Hugues),Macé-Aimé(Gaëtane),Ro… Hum Mol Genet 2008-03-14

...RAD17 are required for DNA interstrand cross-link (ICL) resistance and for the optimal activation of FANCD2. Moreover, w...

Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.

Kim(J M),Kakusho(N),Yamada(M),Kanoh(Y),Takem… Oncogene 2008-06-24

...Rad17 are relocated to chromatin in these cells following HU treatment, indicating that stalled DNA replication forks ar...

Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase coopera…

Liu(Xiaojun),Matsuda(Akira),Plunkett(William) Mol Cancer Ther 2008-04-03

...Rad17 and its phosphorylated form were increased on CNDAC exposure, suggesting activation of ATR kinase. The G2 checkpoi...

Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to g…

Gabai(Vladimir L),O'Callaghan-Sunol(Cornelia… Cancer Res 2008-04-09

...Rad17 was also suppressed, whereas phosphorylation of p53 at Ser(15) was not affected, indicating a specific defect in p...

Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re…

Rakotomalala(Lova),Studach(Leo),Wang(Wen-Hor… J Biol Chem 2008-11-25

...RAD17 and H2AX. Interestingly, phospho-H2AX-positive and BrdUrd -positive cells progress through mitosis, demonstrating ...

Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.

Morin(Isabelle),Ngo(Hien-Ping),Greenall(Aman… EMBO J 2008-10-23

...Rad17, Rad9, Rad53 and Mec1, but is largely independent of Chk1, Tel1 and Dun1. Serines S372, S567, S587 and S692 of Exo...

Suppressed expression of non-DSB repair genes inhibits gamma-radiation-induced …

Zhang(Ye),Rohde(Larry H),Emami(Kamal),Hammon… DNA Repair (Amst) 2008-12-29

...RAD17 and RBBP8 (cell cycle control). Knocked-down expression of four genes (MRE11A, RAD51 in the DSB pathway, SESN1, an...

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