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Embryonic stem cell-derived neurons as a cellular system to study gene function…

Schrenk-Siemens(K),Perez-Alcala(S),Richter(J… Stem Cells 2008-08-00

...Aplp2 die early postnatally without any obvious histopathological abnormalities. Here we show that glutamatergic neurons...

Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is requir…

Cheng(F),Cappai(R),Lidfeldt(J),Belting(M),Fr… J Biol Chem 2014-07-25

...APLP2) by β- and γ-secretases into amyloid β(A) and Aβ-like peptides also takes place in these compartments. Moreover, a...

Quantitation and localization of intracellular redox active metals by X-ray flu…

Ciccotosto(GD),James(SA),Altissimo(M),Paters… Metallomics 2014-10-00

The amyloid precursor protein (APP) gene family includes APP and the amyloid precursor-like proteins, APLP1 and APLP2. T...

Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular ca…

Tao(Z),Huang(J),Li(J) Environ Toxicol 2024-02-00

...APLP2 regulated the LIHC progression. Two cell lines of LIHC cells, HepG2, and Huh7, were used for si-APLP2 transfection...

Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and …

Sliker(BH),Goetz(BT),Peters(HL),Poelaert(BJ)… Cancer Biol Ther 2019-00-00

...APLP2 in S2-013 and PANC-1 but heightened the level of APLP2 in MIA PaCa-2 cells, consistent with our migration data and...

FE65 and FE65L1 share common synaptic functions and genetically interact with t…

Strecker(P),Ludewig(S),Rust(M),Mundinger(TA)… Sci Rep 2016-00-11

...APLP2-DKO mice lacking the FE65/FE65L1 binding site, the NMJs of APLP2/FE65-DKO and APLP2/FE65L1-DKO mice were analyzed....

A single amino acid difference between the intracellular domains of amyloid pre…

Trillaud-Doppia(E),Paradis-Isler(N),Boehm(J) Neurobiol Dis 2016-00-00

...APLP2-ICD. The alanine in APP-ICD and the proline in APLP2-ICD lie directly behind a conserved caspase cleavage site. In...

APLP2, a member of the Alzheimer precursor protein family, is required for corr…

Rassoulzadegan(M),Yang(Y),Cuzin(F) EMBO J 1998-08-17

...Aplp2 +/- embryonic fibroblasts following transfection of an expression vector for Aplp2 antisense RNA with green fluore...

Amyloid precursor-like protein 2 C-terminal fragments upregulate S100A9 gene an…

Li(G),Chen(H),Cheng(L),Zhao(R),Zhao(J),Xu(Y) Neural Regen Res 2014-11-01

...APLP2-751 resulted in low levels of S100A9 protein expression. Our results show that APLP2-CTFs upregulate S100A9 protei...

Association of intracellular proteins with folded major histocompatibility comp…

Morris(CR),Reber(AJ),Petersen(JL),Vargas(SE)… Immunol Res 2004-00-00

...APLP2), interact specifically and stably with MHC class I molecules that have folded peptide-binding grooves. Invariant ...

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