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ATR pathway is the primary pathway for activating G2/M checkpoint induction aft…

Lin(Jie Jessie),Dutta(Anindya) J Biol Chem 2007-12-12

...Rad17-RFC clamp loader. ATM kinase and the Mre11-Rad50-Nbs1 complex do not appear to play significant roles in the check...

Clamping the Mec1/ATR checkpoint kinase into action.

Majka(Jerzy),Burgers(Peter M J) Cell Cycle 2007-12-13

...Rad17-Mec3-Ddc1 (human 9-1-1) is loaded onto gapped DNA resulting from the partial repair of DNA damage, and the Ddc1 su...

The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replic…

Boerckel(Julie),Walker(Dana),Ahmed(Shawn) Genetics 2007-09-13

...Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA d...

Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolate…

Roy(Molay Kumar),Kobori(Masuko),Takenaka(Mak… Planta Med 2007-01-03

...Rad17. At G0/G1 cell cycle arrest, modulation in the expression of the cell cycle regulatory molecules was also observed...

Repression of new p53 targets revealed by ChIP on chip experiments.

Ceribelli(Michele),Alcalay(Myriam),Viganò(Ma… Cell Cycle 2007-05-01

...RAD17) is consistent with a feedback loop regulation on p53 levels. Finally, there is a large overlap (66%) between p53 ...

ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphoryl…

Wakeman(Timothy P),Xu(Bo) Mutat Res 2007-01-03

...Rad17 is required for this process. Taken together, these results indicate that the Rad17-ATR-SMC1 pathway is essential ...

Pathogenic and apathogenic courses of SIV infection are associated with distinc…

Bostik(Pavel),Noble(Erika S),Villinger(Franc… AIDS Res Hum Retroviruses 2007-01-10

...RAD17. Therefore SIV infection in rhesus macaques and sooty mangabeys exhibits distinct and reproducible effects on cell...

Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in b…

Wu(Hsin-Yen),Burgess(Sean M) Curr Biol 2007-03-05

...Rad17, a component of a PCNA clamp-like complex, and Pch2, a putative AAA-ATPase . We show that two genetically separabl...

The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage …

Majka(Jerzy),Niedziela-Majka(Anita),Burgers(… Mol Cell 2007-01-25

...Rad17/Mec3/Ddc1 (the 9-1-1 complex in human) and its loader Rad24-RFC are also essential components of this signal trans...

Cyclin and cyclin-dependent kinase substrate requirements for preventing rerepl…

Ikui(Amy E),Archambault(Vincent),Drapkin(Ben… Genetics 2007-10-15

...Rad17 provide additional mechanisms that maintain viability and also prevent further rereplication, and this probably co...

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