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Evolutionary distance of amino acid sequence orthologs across macaque subspecie…

Ross(Cody T),Roodgar(Morteza),Smith(David Gl… PLoS One 2016-01-18

...RAD50, and TM9SF2 were identified as possible candidates, among others. We failed to find many laboratory experiments co...

Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DN…

Park(Caroline),Suh(Yousin),Cuervo(Ana Maria) Nat Commun 2016-04-05

...Rad50-Nbs1) complex, which participates in early steps of particular DNA repair pathways. We propose that CMA contribute...

Efficient 5'-3' DNA end resection by HerA and NurA is essential for cell viabil…

Huang(Qihong),Liu(Linlin),Liu(Junfeng),Ni(Ji… BMC Mol Biol 2016-01-07

...Rad50.,We revealed that each of the four genes in the same operon, mre11, rad50, herA, and nurA, are essential for cell ...

Targeting of the EGFR/β1 integrin connecting proteins PINCH1 and Nck2 radiosens…

Rossow(Lydia),Eke(Iris),Dickreuter(Ellen),Co… Oncol Rep 2016-03-29

...Rad50 and Nbs1 expression but without changes in other DNA repair proteins such as ATM, DNA-PK and Mre11. Our data sugge...

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NB…

Lee(Kyung Yong),Im(Jun-Sub),Shibata(Etsuko),… Nat Commun 2016-04-13

...RAD50-NBS1) at DSBs to generate ssDNA. MCM8-9 interacts with MRN and is required for the nuclease activity and stable as...

Targeted Resequencing of 30 Genes Improves the Detection of Deleterious Mutatio…

Rajkumar(Thangarajan),Meenakumari(Balaiah),M… Asian Pac J Cancer Prev 2016-05-05

...RAD50, RAD52, ATM and TP53BP1. Some 19 deleterious mutations were seen in patients who had been tested earlier with PCR-...

ATM-dependent phosphorylation of MRE11 controls extent of resection during homo…

Kijas(Amanda W),Lim(Yi Chieh),Bolderson(Emma… Nucleic Acids Res 2016-01-11

The MRE11/RAD50/NBS1 (MRN) complex plays a central role as a sensor of DNA double strand breaks (DSB) and is responsible...

Overhang polarity of chromosomal double-strand breaks impacts kinetics and fide…

Liang(Zhuobin),Sunder(Sham),Nallasivam(Sivak… Nucleic Acids Res 2016-08-24

...Rad50-Xrs2 rapidly modified 5' DSBs and facilitated protection of 3' DSBs, likely through recognition of overhang polari...

The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of General Transcription …

Bridges(Rebecca G),Sohn(Sook-Young),Wright(J… MBio 2016-10-12

...Rad50-Nbs1 DNA repair complex through relocalization. E4-ORF3 also induces SUMOylation of Mre11 and Nbs1. We recently id...

Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibit…

Zhang(Min),Liu(Guoyan),Xue(Fengxia),Edwards(… Gynecol Oncol 2016-08-16

...RAD50 deletion is a marker of BRCAness. The RAD50 deletion occurred in 18% of BRCAwt OvCa patients. RAD50 deletion led t...

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