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DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibit…

Diamant(Noam),Hendel(Ayal),Vered(Ilan),Carel… Nucleic Acids Res 2012-02-27

...Rev1. Analysis of TLS using a high-resolution gapped-plasmid assay system in cell populations enriched by centrifugal el...

Defining the metabolic syndrome: Resolving unresolved issues?

Olijhoek(Jobien K),van der Graaf(Yolanda),Ha… Eur J Intern Med 2012-10-02

...rev1, the use of lipid-lowering agents fulfilled the hypertriglyceridemia criterion; in NCEP-rev2, triglycerides and HDL...

DNA polymerase ζ is a major determinant of resistance to platinum-based chemoth…

Sharma(Shilpy),Shah(Nicholas A),Joiner(Ariel… Mol Pharmacol 2012-07-16

...REV1, and Polζ. Because oxaliplatin, satraplatin, and picoplatin contain bulkier chemical groups attached to the platinu...

Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caus…

Baruffini(Enrico),Serafini(Fausta),Ferrero(I… PLoS One 2012-08-03

...Rev1, involved in the error-prone translesion synthesis during replication of nuclear DNA, localize also in mitochondria...

MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplati…

Wang(Yemin),Huang(Jen-Wei),Calses(Philamer),… Cancer Res 2012-12-04

...REV1 are required for resistance to DNA interstrand cross-linking agents such as cisplatin. In this study, we show that ...

NMR structure and dynamics of the C-terminal domain from human Rev1 and its com…

Pozhidaeva(Alexandra),Pustovalova(Yulia),D'S… Biochemistry 2012-12-07

...Rev1 C-terminal domain (Rev1-CT). We used NMR spectroscopy to determine the spatial structure of the Rev1-CT domain (res...

Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA p…

Zhao(Linlin),Pence(Matthew G),Christov(Plame… J Biol Chem 2012-12-31

...REV1 yielded only 1-base incorporation. Steady-state kinetics revealed that dCTP incorporation is preferred opposite N(2...

The C-terminal domain of human Rev1 contains independent binding sites for DNA …

Pustovalova(Yulia),Bezsonova(Irina),Korzhnev… FEBS Lett 2012-12-05

Human Rev1 is a translesion synthesis (TLS) DNA polymerase involved in bypass replication across sites of DNA damage and...

Repair of cisplatin-induced DNA interstrand crosslinks by a replication-indepen…

Enoiu(Milica),Jiricny(Josef),Schärer(Orlando… Nucleic Acids Res 2012-12-28

...Rev1 and Polζ are involved in the error-free bypass of cisplatin ICLs. The requirement for CSB, Rev1 or Polζ is specific...

[Treatment of mild exacerbations of chronic obstructive pulmonary disease].

Kliachkina(I L),Dmitriev(Iu K) Klin Med (Mosk) 2012-08-07

...REV1, number of inhalations). Therapy decreased the intensity and frequency of daytime and especially night-time coughin...

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