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Copper and zinc ions govern the trans-directed dimerization of APP family membe…

August(A),Schmidt(N),Klingler(J),Baumkötter(… J Neurochem 2019-00-00

The amyloid precursor protein (APP) and its homologs amyloid precursor-like protein 1 (APLP1) and APLP2 have central phy...

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all th…

Herms(J),Anliker(B),Heber(S),Ring(S),Fuhrman… EMBO J 2004-10-13

...APLP2. We previously documented that APLP2-/-APLP1-/- and APLP2-/-APP-/- mice die postnatally, while APLP1-/-APP-/- mice...

Expression of the APP gene family in brain cells, brain development and aging.

Sandbrink(R),Mönning(U),Masters(CL),Beyreuth… Gerontology 1997-00-00

...APLP2. Omission of the latter exons in L-APP and L-APLP2 isoforms, respectively, generates a functional recognition sequ...

PAT1a modulates intracellular transport and processing of amyloid precursor pro…

Kuan(YH),Gruebl(T),Soba(P),Eggert(S),Nesic(I… J Biol Chem 2006-12-29

...APLP2 (APLPs), are processed in a very similar manner by the same protease activities. A putative candidate involved in ...

Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins.

Suzuki(T),Ando(K),Iijima(K),Oguchi(S),Takeda… Methods Mol Med 2000-00-00

...APLP2 have a similar physiological function (9). In contrast, APLP1 is believed to differ functionally from APP and APLP...

A single tyrosine residue in the amyloid precursor protein intracellular domain…

Barbagallo(AP),Wang(Z),Zheng(H),D'Adamio(L) J Biol Chem 2011-03-18

...APLP2) knock-out background showed that mutation of Tyr(682) results in postnatal lethality and neuromuscular synapse de...

Quantification of presenilin-1 mRNA in Alzheimer's disease brains.

Johnston(JA),Froelich(S),Lannfelt(L),Cowburn… FEBS Lett 1996-10-07

...APLP2 mRNAs had previously been quantified in these samples (Johnston et al. (1996) Mol. Brain Res., in press) and subje...

IGF-1-induced processing of the amyloid precursor protein family is mediated by…

Adlerz(L),Holback(S),Multhaup(G),Iverfeldt(K) J Biol Chem 2007-04-06

...APLP2). The neurotoxic amyloid beta-peptide (Abeta) originates from APP, which is the only member of this protein family...

Expression and potential function of beta-amyloid precursor proteins during cut…

Kummer(C),Wehner(S),Quast(T),Werner(S),Herzo… Exp Cell Res 2002-11-01

...APLP2), during cutaneous wound repair using a full-thickness excisional wound healing model in mice. In unwounded skin A...

The intracellular threonine of amyloid precursor protein that is essential for …

Barbagallo(AP),Wang(Z),Zheng(H),D'Adamio(L) PLoS One 2011-03-22

...APLP2) mice present postnatal lethality and neuromuscular synapse defects. Previous work has shown that the APP intracel...

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