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Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA…

Rahmati(M),Chebli(J),Kumar Banote(R),Roselli… eNeuro 2024-06-00

...aplp2), in zebrafish. The observed transcriptional response of appa and aplp2 required degradation of mutant mRNA and di...

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain…

Schauenburg(L),Liebsch(F),Eravci(M),Mayer(MC… Sci Rep 2018-00-30

...APLP2, is typically a two-step process, which is initiated by ectodomain-shedding of the substrates by α- or β-secretase...

Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precurs…

Jacobsen(KT),Adlerz(L),Multhaup(G),Iverfeldt… J Biol Chem 2010-04-02

...APLP2 shedding is independent of this signaling pathway. Here, we used human neuroblastoma SH-SY5Y cells to investigate ...

Relationships between the Bone Expression of Alzheimer's Disease-Related Genes,…

Stapledon(CJM),Stamenkov(R),Cappai(R),Clark(… Calcif Tissue Int 2021-00-00

...APLP2, BACE1 and NGF levels in NOF bone. Significant correlations were found between APP, APLP2, BACE1 mRNA levels and b...

The role of APP and APLP for synaptic transmission, plasticity, and network fun…

Korte(M),Herrmann(U),Zhang(X),Draguhn(A) Exp Brain Res 2012-04-00

APP, APLP1, and APLP2 form a family of mammalian membrane proteins with unknown function. APP, however, plays a key role...

Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticit…

Mehr(A),Hick(M),Ludewig(S),Müller(M),Herrman… Cereb Cortex 2020-00-01

...APLP2 in excitatory forebrain neurons for spine density, synaptic plasticity, and behavior. Here, we show that APP is al...

Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrin…

Arvidsson(Y),Andersson(E),Bergström(A),Ander… Endocr Relat Cancer 2008-06-00

...APLP2 in NE tumours. Cellular localization of APLP1, APLP2 and amyloid precursor protein (APP) in carcinoid cells (GOT1)...

APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of T…

Castelblanco(E),Zafon(C),Maravall(J),Gallel(… Thyroid 2017-00-00

...APLP2, RRM2, and PRC1 discriminated between benign and malignant lesions with 100% sensitivity in both main and validati...

An Integrative Data Mining and Omics-Based Translational Model for the Identifi…

Long(NP),Jung(KH),Anh(NH),Yan(HH),Nghi(TD),P… Cancers (Basel) 2019-01-29

...APLP2 greatly influenced its decisions. An explanation approach for the RF model was successfully constructed. Moreover,...

APP family is a regulator of endo-lysosomal membrane vulnerability.

Lundin(B),Wieckiewicz(N),Yokomizo(M),Sadek(M… J Biol Chem 2025-11-00

...APLP2) deficient mouse embryonic fibroblast cells is more vulnerable to leakage caused by oxidative stress, adeno-associ...

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