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The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially r…

Sabbioneda(Simone),Minesinger(Brenda K),Gian… J Biol Chem 2006-01-10

...Rad17, and Mec3 form a clamp-like structure (the 9-1-1 clamp) that has physical similarity to the homotrimeric sliding c...

Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpo…

Majka(Jerzy),Burgers(Peter M) DNA Repair (Amst) 2006-01-04

...Rad17, Mec3, and Ddc1 subunits (Rad17/3/1, the 9-1-1 complex in humans) is an early response factor to DNA damage in a s...

BLM is an early responder to DNA double-strand breaks.

Karmakar(Parimal),Seki(Masayuki),Kanamori(Ma… Biochem Biophys Res Commun 2006-11-09

...RAD17, DNA-PKcs, NBS1, XRCC3, RAD52, RAD54, or WRN. Thus, HRDC domain in DNA helicases is a common early responder to DN...

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation i…

Wang(Xin),Zou(Lee),Lu(Tao),Bao(Shilai),Hurov… Mol Cell 2006-09-19

...Rad17 in an ATR-Rad17-Claspin-Chk1-signaling cascade that responds to specific replication stress.

Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro…

Zimmerman(Erik S),Sherman(Michael P),Blacket… J Virol 2006-12-04

...Rad17, and Chk1 protein expression in these nondividing cells. These observations begin to explain the remarkable resili...

Replication protein A directs loading of the DNA damage checkpoint clamp to 5'-…

Majka(Jerzy),Binz(Sara K),Wold(Marc S),Burge… J Biol Chem 2006-11-02

...Rad17, Mec3, and Ddc1 subunits (Rad17/3/1, the 9-1-1 complex in humans). This DNA damage response factor is loaded onto ...

Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replicat…

Taricani(Lorena),Wang(Teresa S F) Mol Biol Cell 2006-10-02

...Rad17 but has a compromised association with Crb3. Furthermore, the damaged-induced Rad9 phosphorylation is significantl...

Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle ar…

Shiotani(Bunsyo),Kobayashi(Masahiko),Watanab… Mol Cancer Res 2006-04-18

...Rad17(-/-) DT40 cells showed greater sensitivity to pierisin-1-induced cytotoxicity than wild-type and ATM(-/-) DT40 cel...

Chk1 is required to maintain claspin stability.

Chini(C C S),Wood(J),Chen(J) Oncogene 2006-08-28

...Rad17 is required for early Chk1 activation after hydroxyurea treatment, Claspin is only required to sustain Chk1 activa...

Overproduction and purification of RFC-related clamp loaders and PCNA-related c…

Bylund(Göran O),Majka(Jerzy),Burgers(Peter M… Methods Enzymol 2006-08-01

...Rad17, Mec3, and Ddc1, was overproduced and purified in a similar manner.

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