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APP family is a regulator of endo-lysosomal membrane vulnerability.

Lundin(B),Wieckiewicz(N),Yokomizo(M),Sadek(M… J Biol Chem 2025-11-00

...APLP2) deficient mouse embryonic fibroblast cells is more vulnerable to leakage caused by oxidative stress, adeno-associ...

The beta A4 amyloid precursor protein binding to copper.

Hesse(L),Beher(D),Masters(CL),Multhaup(G) FEBS Lett 1994-07-25

...APLP2. Copper(II) binding is shown to inhibit homophilic APP binding. The identification of a copper(II) binding site in...

Genomic structure and chromosomal localization of the mouse CDEI-binding protei…

Yang(Y),Martin(L),Cuzin(F),Mattei(MG),Rassou… Genomics 1996-07-01

...APLP2, on the basis of sequence similarities with the Amyloid Precursor Protein (APP). The exon-intron distribution of C...

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP…

Wang(P),Yang(G),Mosier(DR),Chang(P),Zaidi(T)… J Neurosci 2005-02-02

...APLP2) exhibit aberrant apposition of presynaptic marker proteins with postsynaptic acetylcholine receptors and excessiv...

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells beh…

Bergmans(BA),Shariati(SA),Habets(RL),Verstre… Stem Cells 2010-03-31

...APLP2. APP/APLP1/APLP2 triple knockout (APP tKO) mice display cobblestone lissencephaly and are perinatally lethal. To c...

Macroarray analysis in the hypertrophic left ventricle of renin-dependent hyper…

Kurdi(M),Cerutti(C),Randon(J),McGregor(L),Br… J Renin Angiotensin Aldostero… 2004-06-00

...APLP2]) and 19 were underexpressed in the left ventricle of TG+/- compared with TG-/-. APLP2 is a member of the amyloid ...

beta-Secretase cleavage is not required for generation of the intracellular C-t…

Sala Frigerio(C),Fadeeva(JV),Minogue(AM),Cit… FEBS J 2010-03-00

...APLP2. All three proteins undergo ectodomain shedding and regulated intramembrane proteolysis, and important functions h...

Comparative transcriptome profiling of amyloid precursor protein family members…

Aydin(D),Filippov(MA),Tschäpe(JA),Gretz(N),P… BMC Genomics 2011-03-24

...APLP2 knockout (APLP2-/-) and APPsα knockin mice (APPα/α) expressing solely the secreted APPsα ectodomain. Biological pa...

Immunohistochemical profile of non-invasive follicular thyroid neoplasm with pa…

Samaka(RM),Hemida(AS),Alfouly(H),Kora(MA) Diagn Pathol 2025-05-26

...APLP2 IHC markers in NIFTP versus other thyroid follicular lesions and their diagnostic validity was also evaluated. one...

Caspase cleavage of members of the amyloid precursor family of proteins.

Galvan(V),Chen(S),Lu(D),Logvinova(A),Goldsmi… J Neurochem 2002-07-00

...APLP2 are cleaved by caspases at their C-termini. The carboxy-terminal peptide derived from caspase cleavage of APLP1 sh...

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