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The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer ce…

Tahara(Makiko),Inoue(Takeshi),Sato(Futoshi),… Mol Cancer Ther 2015-01-02

...Rad50, increased the sensitivity to olaparib and/or SN-38 treatment in colon cancer cells. In vivo study using mouse xen...

Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migrat…

Gao(Ran),Singh(Rumani),Kaul(Zeenia),Kaul(Sun… J Gerontol A Biol Sci Med Sci 2015-07-20

...RAD50-NBS1) complex, the DNA damage-sensing complex. We demonstrate that the identified shRNAs triggered DNA damage resp...

Altered gene expression signature of early stages of the germ line supports the…

Bonache(S),Algaba(F),Franco(E),Bassas(L),Lar… Andrology 2015-02-09

...RAD50) which suggests that the expression of these genes is critical for a proper germ cell development. Interestingly, ...

Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vit…

Koppensteiner(Romana),Samartzis(Eleftherios … PLoS One 2015-12-09

To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and t...

Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Pr…

Sharma(V),Michel(S),Gaertner(V),Franke(A),Vo… Allergy 2015-06-24

...RAD50-IL13 and IL4), and 12q13 (STAT6) as major susceptibility loci influencing the regulation of total serum IgE levels...

Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN con…

Damiola(Francesca),Pertesi(Maroulio),Oliver(… Breast Cancer Res 2015-04-16

The MRE11A-RAD50-Nibrin (MRN) complex plays several critical roles related to repair of DNA double-strand breaks. Inheri...

A polymorphism in the TH 2 locus control region is associated with changes in D…

Schieck(M),Sharma(V),Michel(S),Toncheva(A A)… Allergy 2015-04-02

Genomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated w...

Mdmx promotes genomic instability independent of p53 and Mdm2.

Carrillo(A M),Bouska(A),Arrate(M P),Eischen(… Oncogene 2015-04-10

...Rad50-Nbs1 (MRN) DNA repair complex, and this association increased upon DNA damage and was detected at chromatin. Eleva...

A functional cancer genomics screen identifies a druggable synthetic lethal int…

Dietlein(Felix),Thelen(Lisa),Jokic(Mladen),J… Cancer Discov 2015-12-14

...RAD50, as being associated with non-oncogene addiction to DNA-PKcs. Mutations in the mismatch repair gene MSH3, which ha...

Next-generation sequencing for the diagnosis of hereditary breast and ovarian c…

Castéra(Laurent),Krieger(Sophie),Rousselin(A… Eur J Hum Genet 2015-06-25

...RAD50, 7/708 in PALB2, 3/708 in MRE11A, 5/708 in ATM, 3/708 in NBS1, 1/708 in CDH1, 3/468 in MSH2, 2/468 in PMS2, 1/708 ...

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