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The Werner's Syndrome protein collaborates with REV1 to promote replication for…

Phillips(Lara G),Sale(Julian E) DNA Repair (Amst) 2011-01-13

...REV1-deficient cells. Here we use the avian cell line DT40 to demonstrate that WRN assists REV1-dependent translesion sy...

Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion …

Sherrer(Shanen M),Fiala(Kevin A),Fowler(Jaso… Nucleic Acids Res 2011-03-07

...Rev1, failed to generate full-length lesion bypass products after 3 h. The results indicate that hPolι generates mutatio...

Translesion synthesis polymerases in the prevention and promotion of carcinogen…

Stallons(L Jay),McGregor(W Glenn) J Nucleic Acids 2011-07-14

...REV1, and Pol ζ) have been studied extensively in vitro, but their in vivo role is only now being investigated using kno...

The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically si…

Wiltrout(Mary Ellen),Walker(Graham C) Genetics 2011-04-20

...Rev1, Pol ζ (Rev3/7), and Pol η (Rad30), all with human homologs. Rev1's noncatalytic role in recruiting other DNA polym...

Crosstalk between replicative and translesional DNA polymerases: PDIP38 interac…

Tissier(Agnès),Janel-Bintz(Régine),Coulon(St… DNA Repair (Amst) 2011-01-03

...Rev1 and Polzeta (via Rev7). We thus suggest that PDIP38 serves as a mediator protein helping TLS Pols to transiently re...

Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharom…

Conde(Francisco),Ontoso(David),Acosta(Isabel… DNA Repair (Amst) 2011-01-13

...Rev1 foci. We propose that threshold levels of Rad53 activity exquisitely modulate the tolerance to alkylating damage at...

DNA polymerases and carcinogenesis.

Krutyakov(V M),Kravetskaya(T P) Biochemistry (Mosc) 2011-03-14

...Rev1, and terminal deoxynucleotidyl transferase, and only polymerases θ and σ manifest a slight 3'-exonuclease activity)...

Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide a…

Brown(Jessica A),Pack(Lindsey R),Fowler(Jaso… Antimicrob Agents Chemother 2011-05-02

...Rev1 incorporating the active, 5'-phosphorylated forms of tenofovir, lamivudine, emtricitabine, and zidovudine. For the ...

Epigenetic instability due to defective replication of structured DNA.

Sarkies(Peter),Reams(Charlie),Simpson(Laura … Mol Cell 2011-01-26

...REV1, a key regulator of DNA translesion synthesis at the replication fork, is required for the maintenance of repressiv...

Rev1, Rev3, or Rev7 siRNA Abolishes Ultraviolet Light-Induced Translesion Repli…

Takezawa(Jun),Ishimi(Yukio),Aiba(Naomi),Yama… J Nucleic Acids 2011-07-14

...Rev1-targeted siRNA also abrogated UV-TLS, indicating that Rev1 is also indispensable to mutagenic TLS. Third, Polη-targ...

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