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Monocyte-to-macrophage differentiation: synthesis and secretion of a complex ex…

Chang(MY),Chan(CK),Braun(KR),Green(PS),O'Bri… J Biol Chem 2012-04-20

...APLP2). Differentiation was also associated with (i) a >500-fold increase in mRNA for TNF-stimulated gene-6, an essentia...

Novel zinc-binding site in the E2 domain regulates amyloid precursor-like prote…

Mayer(MC),Kaden(D),Schauenburg(L),Hancock(MA… J Biol Chem 2014-07-04

...APLP2. We found here that zinc ions bound to APP and APLP1 E2 domains and mediated their oligomerization, whereas the AP...

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit f…

Del Prete(D),Rice(RC),Rajadhyaksha(AM),D'Ada… J Biol Chem 2016-00-12

...APLP2) but not APP-like protein-1 (APLP1). Noteworthy, APLP2, but not APLP1, interacts with Stub1 and CRL4(CRBN), pointi...

Fluorescence resonance energy transfer links membrane ferroportin, hephaestin b…

Dlouhy(AC),Bailey(DK),Steimle(BL),Parker(HV)… J Biol Chem 2019-00-15

...APLP2 in HEK293T cells we used fluorescence and surface biotinylation to quantify Fpn membrane occupancy and also measur...

APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic…

Schilling(S),Mehr(A),Ludewig(S),Stephan(J),Z… J Neurosci 2017-00-24

...APLP2, exhibiting functions that partly overlap with those of APP. Here we tested whether APLP1 and APLP2 also show feat...

The in vivo brain interactome of the amyloid precursor protein.

Bai(Y),Markham(K),Chen(F),Weerasekera(R),Wat… Mol Cell Proteomics 2008-01-00

...APLP2). To rule out sampling bias as an explanation for differences in the individual datasets, a small scale quantitati...

APLP1 promotes dFoxO-dependent cell death in Drosophila.

Wang(X),Ma(Y),Zhao(Y),Chen(Y),Hu(Y),Chen(C),… Apoptosis 2015-06-00

...APLP2). Though the three proteins share similar structures and undergo the same cleavage processing by α-, β- and γ-secr...

Amyloid precursor proteins are constituents of the presynaptic active zone.

Laßek(M),Weingarten(J),Einsfelder(U),Brendel… J Neurochem 2013-10-00

The amyloid precursor protein (APP) and its mammalian homologs, APLP1, APLP2, have been allocated to an organellar pool ...

Contrasting, species-dependent modulation of copper-mediated neurotoxicity by t…

White(AR),Multhaup(G),Galatis(D),McKinstry(W… J Neurosci 2002-01-15

...APLP2)] and its orthologs (including Drosophila melanogaster, Xenopus laevis, and Caenorhabditis elegans), suggesting an...

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage…

Grimm(MO),Mett(J),Stahlmann(CP),Grösgen(S),H… Front Aging Neurosci 2015-00-00

...APLP2 single knock-outs, APP/APLP2 double knock-out, APP-swedish, APP-swedish/PS1Δexon9, and APPΔCT15) confirmed the res...

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