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Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex.

Parrilla-Castellar(Edgardo R),Arlander(Sonne… DNA Repair (Amst) 2005-02-14

...Rad17 play key roles in checkpoint activation. Three of these proteins-Rad9, Hus1, and Rad1-interact in a heterotrimeric...

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 s…

Nakada(Daisuke),Hirano(Yukinori),Sugimoto(Ka… Mol Cell Biol 2004-12-06

...Rad17 complex associates with sites of DNA damage and modulates the Mec1 signaling pathway. However, Ddc1 association wi...

Chromatin association of rad17 is required for an ataxia telangiectasia and rad…

Garg(Renu),Callens(Shannon),Lim(Dae-Sik),Can… Mol Cancer Res 2004-12-17

...Rad17 is crucial for its chromatin association and for the functional effects of ATR activation in response to low-dose ...

The Rad17 homologue of Arabidopsis is involved in the regulation of DNA damage …

Heitzeberg(Fabian),Chen(I-Peng),Hartung(Fran… Plant J 2004-07-15

...RAD17 transcriptionally. AtRAD17 mutants show increased sensitivity to the DNA-damaging chemicals bleomycin and mitomyci...

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

Sancar(Aziz),Lindsey-Boltz(Laura A),Unsal-Ka… Annu Rev Biochem 2004-10-08

...Rad17-RFC complex, and the 9-1-1 complex, to detect DNA damage and to initiate signal transduction cascades that employ ...

Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and H…

Zimmerman(Erik S),Chen(Junjie),Andersen(Josh… Mol Cell Biol 2004-12-03

...Rad17 and Hus1 to induce G(2) arrest as well as Vpr-induced phosphorylation of histone 2A variant X (H2AX) and formation...

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ion…

Stiff(Tom),O'Driscoll(Mark),Rief(Nicole),Iwa… Cancer Res 2004-05-19

...Rad17. However, by phosphorylating H2AX, DNA-PK can contribute to the presence of the damage response proteins MDC1 and ...

Requirement for ATP by the DNA damage checkpoint clamp loader.

Majka(Jerzy),Chung(Brian Y),Burgers(Peter M … J Biol Chem 2004-07-21

...Rad17, Mec3, and Ddc1 (Rad17/3/1) onto partial duplex DNA in an ATP-dependent manner. Interactions between the clamp loa...

Critical role for chicken Rad17 and Rad9 in the cellular response to DNA damage…

Kobayashi(Masahiko),Hirano(Atsushi),Kumano(T… Genes Cells 2004-11-22

...Rad17-replication factor C (Rad17-RFC) and Rad9-Rad1-Hus1 complexes are thought to function in the early phase of cell-c...

Expanded CAG repeats activate the DNA damage checkpoint pathway.

Lahiri(Mayurika),Gustafson(Tanya L),Majors(E… Mol Cell 2004-09-03

...RAD17 or RAD24 have only a modest effect on TNR fragility, indicating that signaling down the Rad9 pathway and not the R...

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