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Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is br…

Matsuda(S),Matsuda(Y),D'Adamio(L) J Biol Chem 2003-10-03

...APLP2, to Klc1. These results support a model where JIP1 mediates the interaction of AbetaPP to the motor protein kinesi...

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like prot…

Li(Q),Südhof(TC) J Biol Chem 2004-03-12

...APLP2, but only APP is known to be cleaved by BACE 1 and to be involved in Alzheimer disease. We now demonstrate that si...

The amyloid precursor protein and postnatal neurogenesis/neuroregeneration.

Chen(Y),Tang(BL) Biochem Biophys Res Commun 2006-03-03

...APLP2) which lack the Abeta sequence, however, suggest that these might have important physiological functions that are ...

Delineation of the functional domains of the extracellular region of YWK-II Pro…

Zhuang(D),Wang(Y),Yang(C),Qiao(Y),Miao(S),Ko… Front Biosci 2006-09-01

...APLP2, is a member of the amyloid precursor protein (APP) superfamily and is a type I transmembrane protein involved in ...

Genetic dissection of the amyloid precursor protein in developmental function a…

Li(H),Wang(Z),Wang(B),Guo(Q),Dolios(G),Tabuc… J Biol Chem 2010-10-01

...APLP2)-null mice results in similar neuromuscular synapse defects and early postnatal lethality as compared with mice do...

Amyloid precursor protein knockout diminishes synaptic vesicle proteins at the …

Laßek(M),Weingarten(J),Acker-Palmer(A),Bajja… Curr Alzheimer Res 2014-00-00

...APLP2 resulted in an increase in synaptophysin, synaptogamin-1, and SV2A abundance. When transmembrane APP is lacking in...

Regulation of gene expression by the APP family in the adult cerebral cortex.

Cha(HJ),Shen(J),Kang(J) Sci Rep 2022-00-07

...APLP2), and they have functional redundancy. APP intracellular c-terminal domain (AICD), produced by sequential α- or β-...

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synapt…

Klevanski(M),Herrmann(U),Weyer(SW),Fol(R),Ca… J Neurosci 2015-12-09

...APLP2, these mice were bred to an APLP2-KO background to generate APPΔCT15-DM double mutants. These APPΔCT15-DM mice wer...

Clioquinol mediates copper uptake and counteracts copper efflux activities of t…

Treiber(C),Simons(A),Strauss(M),Hafner(M),Ca… J Biol Chem 2004-12-10

...APLP2 extracellular domains but not the extracellular domain of APLP1 decreased intracellular copper levels. The express...

Differential distribution of Alzheimer's amyloid precursor protein family varia…

Fardilha(M),Vieira(SI),Barros(A),Sousa(M),Da… Ann N Y Acad Sci 2007-01-00

...APLP2) is highly expressed in testis and sperm, but failed to unambiguously prove the presence of APP itself in mammalia...

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