...APLP2, to Klc1. These results support a model where JIP1 mediates the interaction of AbetaPP to the motor protein kinesi...
...APLP2, but only APP is known to be cleaved by BACE 1 and to be involved in Alzheimer disease. We now demonstrate that si...
...APLP2) which lack the Abeta sequence, however, suggest that these might have important physiological functions that are ...
...APLP2, is a member of the amyloid precursor protein (APP) superfamily and is a type I transmembrane protein involved in ...
...APLP2)-null mice results in similar neuromuscular synapse defects and early postnatal lethality as compared with mice do...
...APLP2 resulted in an increase in synaptophysin, synaptogamin-1, and SV2A abundance. When transmembrane APP is lacking in...
...APLP2), and they have functional redundancy. APP intracellular c-terminal domain (AICD), produced by sequential α- or β-...
...APLP2, these mice were bred to an APLP2-KO background to generate APPΔCT15-DM double mutants. These APPΔCT15-DM mice wer...
...APLP2 extracellular domains but not the extracellular domain of APLP1 decreased intracellular copper levels. The express...
...APLP2) is highly expressed in testis and sperm, but failed to unambiguously prove the presence of APP itself in mammalia...
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