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Viral and Cellular Genomes Activate Distinct DNA Damage Responses.

Shah(Govind A),O'Shea(Clodagh C) Cell 2015-11-24

...RAD50/NBS1 (MRN) activates a global ATM DNA damage response (DDR) that prevents cellular replication. Here, we show that...

Biochemical and Functional Characterization of the NurA-HerA Complex from Deino…

Cheng(Kaiying),Chen(Xuanyi),Xu(Guangzhi),Wan… J Bacteriol 2015-08-11

...Rad50 complex, function in 3' single-stranded DNA (ssDNA) end processing during homologous recombination (HR). However, ...

Deficiency of the DNA repair protein nibrin increases the basal but not the rad…

Wessendorf(Petra),Vijg(Jan),Nussenzweig(Andr… Mutat Res 2015-06-12

...RAD50. The complex is associated particularly with the repair of DNA double strand breaks and with the regulation of cel...

DNA damage foci: Meaning and significance.

Rothkamm(Kai),Barnard(Stephen),Moquet(Jayne)… Environ Mol Mutagen 2015-09-30

...RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form...

ATM has a major role in the double-strand break repair pathway dysregulation in…

Rondeau(S),Vacher(S),De Koning(L),Briaux(A),… Br J Cancer 2015-05-13

...Rad50 (P=0.0064), and TP53BP1 (P=0.026), but not with proteins involved in other pathways that are altered in cancer. Lo...

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex fr…

Chen(Huan),Donnianni(Roberto A),Handa(Naofum… Proc Natl Acad Sci U S A 2015-07-24

...Rad50-Xrs2/NBS1 (MRX/N) nuclease/ATPase complex plays structural and catalytic roles in the repair of DNA double-strand ...

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homolo…

Cejka(Petr) J Biol Chem 2015-12-14

...Rad50-Xrs2 and Sae2, as well as processive long-range resection by Sgs1-Dna2 or Exo1 pathways. Resection mechanisms are ...

High frequency of the SDK1:AMACR fusion transcript in Chinese prostate cancer.

Zhang(Yanling),Mao(Xue-Ying),Liu(Xiaoyan),So… Int J Clin Exp Med 2015-12-02

...RAD50:PDLIM4, CTAGE5:KHDRBS3 and USP9Y:TTTY15 have been reported in Chinese CaP samples through a transcriptome sequenci...

Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evol…

Yamaguchi(Takuya),Takizawa(Fumio),Fischer(Uw… Biology (Basel) 2015-11-23

...RAD50 and bona fide genes of both IL-4/13 and IL-3/ IL-5/GM-CSF families.

Stemness factor Sall4 is required for DNA damage response in embryonic stem cel…

Xiong(Jianhua),Todorova(Dilyana),Su(Ning-Yua… J Cell Biol 2015-04-28

...Rad50 and stabilizes the Mre11-Rad50-Nbs1 complex for the efficient recruitment and activation of ATM. Sall4 also intera...

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