...rad50, nbs1, ku70 and lig4 mutants of P. patens and compare the impact of these mutations in double-strand-break (DSB) r...
...Rad50/Nbs1) is impaired. Cells with impaired MRN complex experienced severe replication stress and gained substrates for...
...Rad50/NBS1 (MRN) and CtIP at DSBs. Moreover, we show that BRCA1 is ubiquitinated by SCF(Skp2) and that abrogation of Chk...
...RAD50 in a general and gene-targeted approach. Inclusion was restricted to studies that sequenced the germline DNA in bo...
...Rad50. We constructed mutations to perturb this domain in the bacteriophage T4 Rad50 homolog. Deletion of the Rad50 coil...
...Rad50-Nbs1 (MRN) complex is required in both steps. We isolated multiple S. pombe ctp1 mutants deficient in clipping but...
...Rad50 and a structural maintenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of phy...
...Rad50-Nbs1 (MRN) complex, a major player of the DDR induced by double-stranded DNA breaks and stalled replication forks,...
...Rad50 (GdRad50) proteins. Our results show that while purified recombinant GdMre11 and GdRad50 proteins bind DNA, GdMre1...
...RAD50, which have been implicated in breast and ovarian cancer predisposition. A total of 129 non-synonymous mutations w...
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