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Telomere dynamics in the lower plant Physcomitrella patens.

Fojtová(Miloslava),Sýkorová(Eva),Najdekrová(… Plant Mol Biol 2015-06-09

...rad50, nbs1, ku70 and lig4 mutants of P. patens and compare the impact of these mutations in double-strand-break (DSB) r...

Replication fork integrity and intra-S phase checkpoint suppress gene amplifica…

Kondratova(Anna),Watanabe(Takaaki),Marotta(M… Nucleic Acids Res 2015-06-22

...Rad50/Nbs1) is impaired. Cells with impaired MRN complex experienced severe replication stress and gained substrates for...

Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end r…

Parameswaran(Balaji),Chiang(Huai-Chin),Lu(Yu… Cell Cycle 2015-12-02

...Rad50/NBS1 (MRN) and CtIP at DSBs. Moreover, we show that BRCA1 is ubiquitinated by SCF(Skp2) and that abrogation of Chk...

Protein-truncating variants in moderate-risk breast cancer susceptibility genes…

Aloraifi(Fatima),McCartan(Damian),McDevitt(T… Cancer Genet 2015-11-17

...RAD50 in a general and gene-targeted approach. Inclusion was restricted to studies that sequenced the germline DNA in bo...

Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Do…

Barfoot(Tasida),Herdendorf(Timothy J),Behnin… J Biol Chem 2015-12-17

...Rad50. We constructed mutations to perturb this domain in the bacteriophage T4 Rad50 homolog. Deletion of the Rad50 coil...

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand…

Ma(Lijuan),Milman(Neta),Nambiar(Mridula),Smi… Nucleic Acids Res 2015-12-15

...Rad50-Nbs1 (MRN) complex is required in both steps. We isolated multiple S. pombe ctp1 mutants deficient in clipping but...

Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kin…

Dong(Qian),Ernst(Sarah E),Ostedgaard(Lynda S… J Biol Chem 2015-08-18

...Rad50 and a structural maintenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of phy...

Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication…

Millet(Rachel),Jolinon(Nelly),Nguyen(Xuan-Nh… J Virol 2015-08-24

...Rad50-Nbs1 (MRN) complex, a major player of the DDR induced by double-stranded DNA breaks and stalled replication forks,...

MR (Mre11-Rad50) complex in Giardia duodenalis: In vitro characterization and i…

Sandoval-Cabrera(A),Zarzosa-Álvarez(A L),Mar… Biochimie 2015-12-04

...Rad50 (GdRad50) proteins. Our results show that while purified recombinant GdMre11 and GdRad50 proteins bind DNA, GdMre1...

A Comparative Analysis of Breast and Ovarian Cancer-related Gene Mutations in C…

Amemiya(Yutaka),Bacopulos(Stephanie),Al-Shaw… Anticancer Res 2015-08-06

...RAD50, which have been implicated in breast and ovarian cancer predisposition. A total of 129 non-synonymous mutations w...

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