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Cross-Regional Transcriptome Data Reveal Transcriptional Abnormalities Associat…

Zhang(L),Fan(C),Shang(H),Wang(X),Zhang(X),Qi… Rep Biochem Mol Biol 2025-04-00

...AIMP2 was significantly negatively correlated with the ASMR and MIR. Our findings suggest that the expression levels of ...

Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent n…

Lee(MH),Um(KH),Lee(SW),Sun(YJ),Gu(DH),Jo(YO)… Acta Neuropathol Commun 2024-00-03

...AIMP2 aberrantly activates PARP-1 through direct physical interaction. Although AIMP2 ought to be a therapeutic target f...

Brain-targeted delivery of neuroprotective survival gene minimizing hematopoiet…

Lee(MH),Kang(S),Um(KH),Lee(SW),Hwang(H),Baek… J Transl Med 2024-00-13

...AIMP2, known to be implicated in Parkinson's disease, into the vector. This configuration ensured that transgene express...

The therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progre…

Park(S),Oh(AY),Hong(BS),Shin(YJ),Jang(H),Seo… Mol Ther Oncol 2024-12-19

...AIMP2 and AIMP2-DX2 (DX2) have been reported to be associated with human lung cancer. In fact, DX2 expression is elevate...

AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in …

Kim(H),Shin(JY),Ham(S),Kim(JH),Lee(GH),Lee(N… J Transl Med 2024-10-10

...AIMP2 in brains of conditional AIMP2 transgenic mice and postmortem PD patients. The pathological role of AIMP2 was inve...

An extensive in silico analysis of missense mutations of the human AIMP2 gene.

Farrokhi(S),Eslahi(A),Alizadeh(F),Farshchian… Heliyon 2024-10-30

...AIMP2) gene. In silico analysis of SNVs (single nucleotide variants) in the AIMP2 gene is an efficient and cost-effectiv...

Identification and structure of AIMP2-DX2 for therapeutic perspectives.

Kim(HJ),Jeong(MS),Jang(SB) BMB Rep 2024-07-00

...AIMP2-DX2) lacking the second exon. AIMP2-DX2 binds to FBP, TRAF2, and p53 similarly to AIMP2, but competes with AIMP2 f...

AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradatio…

Ren(J),Yu(L),Zhang(Q),Ren(P),Cai(Y),Wang(X),… Virol Sin 2024-08-00

...AIMP2, capable of binding to 3D polymerase and inhibiting EV71 infection. Subsequent investigations revealed that AIMP2 ...

Chemical induction of the interaction between AIMP2-DX2 and Siah1 to enhance ub…

Kim(DG),Kim(M),Goo(JI),Kong(J),Harmalkar(DS)… Cell Chem Biol 2024-11-21

AIMP2-DX2 (hereafter DX2) is an oncogenic variant of aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AI...

MTCH2 promotes the malignant progression of ovarian cancer through the upregula…

Sun(G),Song(Y),Li(C),Sun(B),Li(C),Sun(J),Xia… Oncol Lett 2024-10-00

...AIMP2 proteins. Knockdown of AIMP2 inhibited the regulatory effect of MTCH2. Co-immunoprecipitation experiments demonstr...

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