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Assessing positive selection in centromere-associated kinetochore proteins ac...

Healey(HM),Gomez(LE),Sheikh(SI),Camel(BR),... bioRxiv 2026-02-16

Centromeres are comprised of long stretches of repetitive DNA that evolve rapidly in organisms across the tree of life. ...

SIRT1 haploinsufficiency recapitulates age-associated subfertility through sp...

Iniesta-Cuerda(M),Valentova(I),Moravec(J),... Biol Direct 2026-03-25

...CENPE), signaling and metabolism (SHIP1, GAK, ABCD4), chromatin regulation (BRD4, MAGEB4), and testicular architecture (...

The Postnatal Lung Maturation Disrupted by Increased Pulmonary Blood Flow and...

Zheng(S),Wang(Z),Xue(Y),Zhang(H),Xiao(Y),H... JACC Asia 2026-08-00

...CENPE) and hyperactive immunity (upregulated NLRP3/IL23R) impairing alveolar/capillary development; 3) suppressed circad...

High-risk HPV E6 induces an aneuploidy-prone chromosome congression defect th...

Seshimo(N),Hori(K),Furuta(R),Hirota(T),Noz... J Virol 2026-06-23

Chromosomal instability is a common feature of malignancies that arises from persistent defects in chromosome segregatio...

Non-centromeric CENP-A regulates epithelial-mesenchymal plasticity and hetero...

Renaud-Pageot(C),Capocefalo(D),Lemaire(S),... Cell Rep 2026-06-23

Centromere protein A (CENP-A), a centromeric histone H3 variant highly expressed in aggressive cancers, promotes epithel...

Immune-related gene signature for predicting biochemical recurrence after RP ...

Lin(Y),Zhou(J) Discov Oncol 2026-07-23

...CENPE is the only common gene and can be used as a prognostic gene of BCR. Cell-based assays validated that CENPF promot...

Mammalian metaphase kinetochores are elastic and require condensin for robust...

Tran(VM),Tao(J),Rux(CJ),Gomez Siu(D),Rosas... J Cell Biol 2026-10-05

The mammalian kinetochore connects chromosomes to dynamic spindle microtubules. To remain attached, it must maintain str...

The CENtral Identity Crisis: Maintaining Centromere Identity in the Male Germ...

Ní Nualláin(A),O'Gorman(BD),Dunleavy(EM) Annu Rev Genet 2026-08-25

Centromeres are chromosomal loci required for accurate chromosome segregation in cell division and are defined epigeneti...

Integrated Mendelian Randomization and Single-Cell Transcriptomics Reveal T C...

Zhang(D),Ren(H),Bai(Y),Han(P) Life (Basel) 2026-08-21

Objective: Patients with systemic lupus erythematosus (SLE) exhibit elevated malignancy risk, with increased bladder can...

Kinetochore-microtubule attachments are strengthened by Cnn1 stabilization of...

Maitra(N),Edwards(DT),Hu(C),Asbury(CL),Big... bioRxiv 2026-07-14

Accurate chromosome segregation requires kinetochores to form robust, load-bearing attachments to dynamic spindle microt...

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