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Bacterial Cofactors for CRISPR Activation.

Wang(Z),Wang(Y),Ji(Q) Biochemistry 2026-03-03

...CRISPR (Acr) proteins have long exemplified the viral counterattack against CRISPR-Cas immunity. By contrast, comparativ...

Omics-aided design genome editing strategy for challenging human immortalized...

Mendoza-Garcia(P),Keith(B),Nordberg(M),Qui... PLoS One None

CRISPR-Cas9 has become a popular genome editing tool for biomedical research and drug development due to its capability ...

NTDscope: A multi-contrast portable microscope for disease diagnosis.

Díaz de León Derby(M),Moussa(ZL),Ng(CF),Bh... PLOS Glob Public Health None

...CRISPR-Cas13a-based assay. The ability to combine the diagnostic capabilities of conventional microscopy with molecular ...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcr...

El-Brolosy(MA),Oak(A),Hoang(AT),Damergi(Y)... Science 2026-02-12

...CRISPR screens, we uncover ILF3 as an RNA binding protein connecting cytoplasmic mRNA decay and transcription during TA ...

Enhancing the specificity of gene editing outcomes by using Cas9 variants in ...

Kim(J),Yoon(J),Chen(J),Lee(J),Lee(HJ),Whit... J Anim Sci 2026-01-08

The CRISPR/Cas9 technology has improved the ability to introduce targeted modifications in cells and embryos in diverse ...

Generation of a SV2A knockout human embryonic stem cell line by CRISPR/Cas9 s...

Yao(F),Qi(X),Yongli(S),Xiaofen(Z) Stem Cell Res 2026-03-00

...CRISPR/Cas9 genome editing technology. The SV2A-knockout embryonic stem cell lines provide a precise in vitro model to d...

CLIM-TIME identifies metastatic microenvironment modulators for T cell therap...

Wang(Y),Hu(W),Xia(R),Yang(X),Gu(Y),Ning(Z)... Cell 2026-03-05

...CRISPR-laser-captured microdissection (LCM) integration mapping of the tumor-immune microenvironment (CLIM-TIME), a scal...

An orthogonal CRISPR/Cpf1 platform for precise spatiotemporal gene regulation...

Zhao(J),Wang(Z),Lu(L),Bu(G),Miao(Z),Zhang(... Cell Rep Methods 2026-02-23

CRISPR-Cas systems enable powerful gene editing and regulation, yet single-modality control often fails to achieve ortho...

CEP290 is Associated With Chromatin Accessibility of Hepatitis B virus cccDNA...

Iwabuchi(S),Li(YY),Sakamoto(T),Imafuku(T),... J Mol Biol 2026-04-01

...CRISPR/Cas9-mediated knockdown or CRISPR-based transcriptional activation demonstrated that CEP290 positively regulates ...

Selective deletion of FGFR1 in AgRP neurons impairs energy homeostasis under ...

Shookster(D),O'Connell(S),Darshan(P),Landr... Mol Metab 2026-03-00

...CRISPR/Cas9 system alongside transgenic models. Deletion of FGFR1 in AgRP neurons disrupted energy homeostasis, promotin...

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