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Comprehensive clinical and genomic analysis of early onset cancer of the bladde…

Truong(H),Eichholz(J),White(C),Ostrovnaya(I)… J Natl Cancer Inst 2026-07-16

...ERCC2 were observed in patients with very early-onset disease. EO-UC represents a biologically distinct subset character...

microRNA miR-31-5p confers protection to melanin-deficient vitiligo keratinocyt…

Chowdhary(M),Raina(A),Priya(A),Kundu(A),Gupt… Sci Rep 2026-06-02

...ERCC2, XPC), while alleviating replication stress. SP1 was identified as a direct target of miR-31-5p, and its suppressi...

Primary Neuroendocrine Tumors of the Genitourinary System: Two Rare Examples of…

Manzo(R),Renavikar(PS),Cushman-Vokoun(A),Wag… Int J Surg Pathol 2026-02-00

...ERCC2 gene in this tumor that has been described as a pathogenic variant in autosomally recessive conditions. These lesi...

Single-nucleotide polymorphisms in DNA repair genes ERCC, XRCC, and MGMT and im…

Afshar(Y),Naseri(A),Amoozadehsamakoosh(A),Na… J Biomol Struct Dyn 2026-06-00

...ERCC2, and MGMT. Structural Alphafold models were built. Eight molecular dynamics simulation (MDS) runs for up to 100 ns...

Development of a predictive model for neutropenia risk in Japanese breast cance…

Miyagi(T),Tsuji(D),Nakatani(E),Sahara-Ishino… Br J Clin Pharmacol 2026-01-00

...ERCC2 rs238406 and XRCC3 rs709399. The model had an AUC of 0.744 (95% CI, 0.666-0.823), and including genetic polymorphi...

Association between ERCC2 Lys751Gln, Asp312Asn, and Arg156Arg polymorphisms and…

Chen(F),Yu(J),Wang(CG) Front Oncol 2025-00-00

...ERCC2) plays a critical role in nucleotide excision repair. Polymorphisms in ERCC2 can influence DNA damage repair mecha...

Trichothiodystrophy-causative pathogenic variants impair a cooperative action o…

Ferri(D),Branca(G),Lanzafame(M),Gandolfi(E),… Nucleic Acids Res 2025-07-19

...ERCC2/XPD gene give rise to xeroderma pigmentosum (XP) or trichothiodystrophy (TTD), two distinct clinical entities with...

Genetic variants and clinical determinants affecting the response to 5-Fluorour…

Cerpa(LC),Sandoval(C),Escalante(P),Cayún(JP)… Front Oncol 2025-00-00

...ERCC2, ABCB1, ABCC2, ABCC4, and ABCG2 genes, which, combined with clinical factors, could contribute to a predictive mod...

Quantitative functional profiling of ERCC2 mutations deciphers cisplatin sensit…

Börcsök(J),Gopaul(D),Devesa-Serrano(D),Moose… J Clin Invest 2025-08-15

...ERCC2 carries heterozygous missense mutations in approximately 10% of bladder tumors, and these may predict sensitivity ...

Prediction of response to neoadjuvant chemotherapy in patients with muscle-inva…

Mahmoud(H),Abd El-Aziz(AM),Ezzat(O),Kenawy(H… Cancer Immunol Immunother 2025-07-30

This prospective study aimed at investigating the role of immune-related gene expression (GATA3, METTL3, ERCC2, PD-L1 an...

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