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Elevated mutation in haploid yeast driven by error-prone Rev1 polymerase.

Fredette-Roman(J),Smith(DR),Omari(SB),Sharp(… Genetics 2026-07-15

...REV1+ haploids than in REV1+ diploids. Deleting the REV1 gene caused this difference to vanish, with mutation rates in h...

Pathogenesis of Brucella abortus and Brucella melitensis in bovine and ovine-de…

Elizalde-Bielsa(A),Loperena-Barber(M),Pfarre… Vet Res 2026-07-07

...Rev1 vaccine strain. Although its initial rate of infection was comparable to B. melitensis 16M, Rev1 exhibited a delay ...

A sibling study of variation in parental mutation rates.

Getseva(V),Poyraz(P),Stolyarova(A),Agarwal(I… bioRxiv 2026-05-15

...REV1 and LIG1 increase germline mutation rates, and thus that rare mutator alleles segregate in population cohorts.

Lnk deficiency enhances translesion synthesis to alleviate replication stress a…

Singh(B),Hossain(MA),Liang(XH),Fages(J),Sala… J Clin Invest 2026-01-02

...REV1 and, to a lesser extent, TLS polymerase eta (η). TLS polymerases are specialized to execute DNA replication in the ...

Enzymatic and Structural Roles of Candida albicans Rev1 in DNA Damage Response …

Sahu(SR),Parida(SS),Utkalaja(BG),Nayak(S),Da… Mol Microbiol 2025-10-00

...Rev1 remains elusive. Here we characterized Rev1 from Candida albicans, an opportunistic fungal pathogen responsible for...

Mutational landscape of pure ductal carcinoma in situ and associations with dis…

Rizvi(N),Mucaki(EJ),Salmini(EL),Zhang(M),Tre… Breast Cancer Res 2025-07-08

...REV1, which mediates DNA damage tolerance, may impair cellular responses to RT-induced stress. Notably, we identified di...

REV1‑targeting inhibitor JH‑RE‑06 induces ferroptosis via NCOA4‑mediated ferrit…

Cheng(J),Yang(X),Zhao(W),Xu(J),Hao(Y),Xu(F) Oncol Rep 2025-12-00

...REV1 (REV1 DNA directed polymerase (REV1) inhibitor JH‑RE‑06 in colorectal cancer (CRC) remains unexplored. Bioinformati...

Methylglyoxal mutagenizes single-stranded DNA via Rev1-associated slippage and …

Vijayraghavan(S),Ruggiero(A),Becker(S),Miecz… Nucleic Acids Res 2025-07-19

...Rev1 is a key player in this pathway. Finally, we find that the primary MG-associated mutation is enriched in a variety ...

The roles of NHEJ and TLS pathways in genomic alterations and phenotypic evolut…

Yan(C),Wang(YK),Xiong(YR),Zhou(XQ),Fang(YC),… Appl Microbiol Biotechnol 2025-08-15

...rev1, rev3, and rad30) are subjected to mutation accumulation experiments, followed by whole-genome sequencing. Our resu...

Unveiling Replication Timing-Dependent Mutational Biases: Mechanistic Insights …

Gross-Samuels(H),Koren(A),Simon(I) Int J Mol Sci 2025-07-29

...REV1) and double-strand break repair (DCLRE1A and PRKDC), DNA polymerases (POLB, POLE3, and POLE4), and other genes cent...

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