Qin(Y),Li(W),Zhu(S),Zhang(S),Fang(R),Kang(... BMC Pregnancy Childbirth 2026-06-10

...RIT1, RAF1, and BRAF) and skeletal disorders (FGFR2, COL1A1, and HSPG2) were the most frequently identified monogenic co...

López-Guillén(JL),Carcavilla(A),Díez-Sebas... Pediatr Res 2026-07-14

...RIT1 (13% each). Patients with Noonan syndrome underwent significantly more therapeutic strategies (p = 0.026). Increase...

Akbaş(ENK),Toksoy(G),Avcı(Ş),Altunoğlu(U),... Clin Genet 2026-07-19

...RIT1, SHOC2, and SOS1. Notably, one patient harbored a variant in AMMECR1, which is not involved in the RAS/MAPK pathway...

Demirtaş(Ş),Özsu(E),Şıklar(Z),Aycan(Z),Kız... J Clin Res Pediatr Endocrin... 2026-06-16

...RIT1 gene. Noonan syndrome may cause gonadal dysfunction leading to delayed puberty and infertility; however, gonadal dy...

Mirzaiebadizi(A),Bazgir(F),Mosaddeghzadeh(... Cells 2026-08-28

...RIT1 and RIT2 are members of the RAS superfamily of small GTPases, which regulate various cellular processes. RIT1 is wi...

Monge(C),Waldrup(B),Carranza(FG),Manjarrez... Int J Mol Sci 2025-08-08

...RIT1 (RTK/RAS), and CTNNB1 (WNT). No significant survival differences were observed in H/L patients, but NHW patients wi...

Tanaka(Y),Ikenoue(S),Ueno(A),Masugi(Y),Yam... Eur J Med Genet 2025-10-00

...RIT1-associated mirror syndrome and non-immune hydrops fetalis (NIHF) further supports the role of Rasopathies in the pa...

Guo(R),Duan(C),Zarrei(M),Reuter(MS),Dong(R... Sci Rep 2025-07-26

...RIT1, and SMAD6. Trio sequencing facilitated the identification of pathogenic variation (55.6% were de novo missense var...

DiMarco(AV),Ravichandran(M),Lau(J),Lima(A)... Cancer Res 2025-09-02

...RIT1 alterations. In this study, we generated a murine model of RIT1M90I-mutant lung cancer. RIT1M90I expression induced...

Mozzarelli(AM),Cuevas-Navarro(A),Shuldiner... Cancer Res 2025-09-02

RIT1 is a small GTPase of the RAS family, and RIT1 mutations have been identified in lung cancer, leukemia, and the deve...