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Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evol…

Yamaguchi(Takuya),Takizawa(Fumio),Fischer(Uw… Biology (Basel) 2015-11-23

...RAD50 and bona fide genes of both IL-4/13 and IL-3/ IL-5/GM-CSF families.

Structure of the Rad50 DNA double-strand break repair protein in complex with D…

Rojowska(Anna),Lammens(Katja),Seifert(Floria… EMBO J 2015-07-08

...Rad50 dimer with main interactions to a strand-loop-helix motif on the NBD. Our analysis suggests that this motif on Rad...

gDNA enrichment by a transposase-based technology for NGS analysis of the whole…

Chevrier(Sandy),Boidot(Romain) J Vis Exp 2015-08-11

...RAD50, RAD51C, RAD80, and TP53) from promoter to 3'-UTR in 24 patients simultaneously. This protocol, based on transposa...

Altered gene expression signature of early stages of the germ line supports the…

Bonache(S),Algaba(F),Franco(E),Bassas(L),Lar… Andrology 2015-02-09

...RAD50) which suggests that the expression of these genes is critical for a proper germ cell development. Interestingly, ...

DNA end recognition by the Mre11 nuclease dimer: insights into resection and re…

Sung(Sihyun),Li(Fuyang),Park(Young Bong),Kim… EMBO J 2015-01-05

...Rad50-Nbs1 (MRN) complex plays important roles in sensing DNA damage, as well as in resecting and tethering DNA ends, an...

The human SRCAP chromatin remodeling complex promotes DNA-end resection.

Dong(Shunli),Han(Jinhua),Chen(Hongxia),Liu(T… Curr Biol 2015-05-28

...RAD50-NBS1 (MRN) complex. However, how this process occurs within the context of chromatin is still not well understood....

Recognition and repair of chemically heterogeneous structures at DNA ends.

Andres(Sara N),Schellenberg(Matthew J),Walla… Environ Mol Mutagen 2015-03-19

...RAD50/NBS1/CtIP complex, Flap endonuclease (FEN1) and the apurinic endonucleases (APE1 and APE2) also act in the chemica...

Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre…

Park(Sujin),Kang(Jin Muk),Kim(Staci Jakyong)… Cell Mol Life Sci 2015-03-17

...Rad50-Nbs1 (MRN) complex play critical roles in the cellular response to DNA damage such as DNA double-strand break (DSB...

Autoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.

Gao(Yang),Nelson(Scott W) J Biol Chem 2015-02-02

...Rad50. Complex formation with Rad50 alleviates this inhibition due to the tight association of the RBD and the Rad50 coi...

End resection at double-strand breaks: mechanism and regulation.

Symington(Lorraine S) Cold Spring Harb Perspect Biol 2015-04-02

...Rad50 and Mre11-Rad50-Xrs2/Nbs1 can play a direct role in end resection in archaea and eukaryota, respectively, by remov...

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