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MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein…

Long(JM),Ray(B),Lahiri(DK) J Biol Chem 2012-09-07

...APLP2. High functional redundancy between APP and APLP2 suggests that miR-153 may target biological pathways in which th...

Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance m…

Afshari(S),Sarailoo(M),Asghariazar(V),Safarz… Hum Exp Toxicol 2024-00-00

...APLP2 protein levels in the PFC, while 12-weeks exposure decreased these levels. Furthermore, expression of APP and APLP...

An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage …

Sala Frigerio(C),Kukar(TL),Fauq(A),Engel(PC)… Biochemistry 2009-11-24

...APLP2 are more similar to APP than any of the other known gamma-secretase substrates and have important physiological ro...

Structural aspects and physiological consequences of APP/APLP trans-dimerizatio…

Baumkötter(F),Wagner(K),Eggert(S),Wild(K),Ki… Exp Brain Res 2012-04-00

...APLP2), participate under physiological conditions via trans-cellular dimerization in synaptogenesis. This offers the po...

The APP family of proteins: similarities and differences.

Walsh(DM),Minogue(AM),Sala Frigerio(C),Fadee… Biochem Soc Trans 2007-04-00

...APLP2. Both APLPs are processed in a manner analogous to APP, with all three proteins subject to ectodomain shedding and...

Family-Based GWAS of Cognitive Endophenotypes Reveals Genetic Architecture of M…

Wang(K),Yang(X),Magwood(G),Xu(C),Navia(RO),N… Curr Issues Mol Biol 2026-04-24

...APLP2 (rs12281267, rs959354), PTPRD (rs1353983, rs970347, rs1392511), NCAM2 (rs2826728), GRM7 (rs6788201), PAX5 (rs29880...

Functions of the APP gene family in the nervous system: insights from mouse mod…

Aydin(D),Weyer(SW),Müller(UC) Exp Brain Res 2012-04-00

...APLP2 in various aspects of nervous system development and function, in particular, for synapse formation and function. ...

Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellul…

Zhou(D),Zambrano(N),Russo(T),D'Adamio(L) J Alzheimers Dis 2009-00-00

...APLP2, the two other members of the AbetaPP-gene family, is abolished by analogous phosphorylation events. Our results i...

Amyloid precursor protein and its homologues: a family of proteolysis-dependent…

Jacobsen(KT),Iverfeldt(K) Cell Mol Life Sci 2009-07-00

...APLP2, the Drosophila APPL, and the C. elegans APL-1. The biological function of APP is still not fully clear. However, ...

Intrafusal-fiber LRP4 for muscle spindle formation and maintenance in adult and…

Cao(R),Chen(P),Wang(H),Jing(H),Zhang(H),Xing… Nat Commun 2023-00-10

...APLP2 on sensory terminals. Finally, spindle sensory endings and function are impaired in aged mice, deficits that could...

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