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Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.

Majka(Jerzy),Burgers(Peter M J) Proc Natl Acad Sci U S A 2003-05-13

...Rad17 forms a complex with Mec3 and Ddc1 (Rad1731) and shows structural similarities with the replication clamp PCNA. Th...

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

Zou(Lee),Elledge(Stephen J) Science 2003-06-26

...Rad17 protein that is bound to DNA. Furthermore, Ddc2, the budding yeast homolog of ATRIP, is specifically recruited to ...

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 pr…

Foray(Nicolas),Marot(Didier),Gabriel(Anastas… EMBO J 2003-07-17

...Rad17, and for the relocalization of Rad9 and Hus1. We propose that BRCA1 facilitates the ability of ATM and ATR to phos...

Validation of a novel assay for checkpoint responses: characterization of campt…

Zhang(Hong),Siede(Wolfram) Mutat Res 2003-07-24

...Rad17 correctly predicts the biological activity of the tested camptothecin derivatives. The used criteria for biologica...

Molecular modeling-based analysis of interactions in the RFC-dependent clamp-lo…

Venclovas(Ceslovas),Colvin(Michael E),Thelen… Protein Sci 2003-03-11

...Rad17 and Ctf18. Based on the individual intermolecular interactions, we propose RFC and PCNA arrangement that places th...

Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early chec…

Roos-Mattjus(Pia),Vroman(Benjamin T),Burtelo… J Biol Chem 2003-01-02

...Rad17 and the four small replication factor C (RFC) subunits (Rad17-RFC) in response to DNA damage. It is unclear what c...

Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damag…

Wang(Hong),Elledge(Stephen J) Genetics 2002-10-08

...Rad17, has been proposed to form a PCNA-like complex and acts upstream in the DNA damage checkpoint pathways. We further...

A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene chec…

Hong(Eun-Jin Erica),Roeder(G Shirleen) Genes Dev 2002-02-28

...Rad17 complex onto chromosomes. Phosphorylation of Ddc1 depends on the meiosis-specific kinase Mek1. In turn, Ddc1 promo...

EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage…

Maringele(Laura),Lydall(David) Genes Dev 2002-09-05

...RAD17, RAD24, MEC3, DDC1, and DUN1 play insignificant roles. We establish that cell cycle arrest of yku70Delta mutants i...

The meiotic recombination checkpoint is regulated by checkpoint rad+ genes in f…

Shimada(Midori),Nabeshima(Kentaro),Tougan(Ta… EMBO J 2002-07-19

...rad17(+)-dependent manner. dmc1Delta also shows meiotic delay, however, this delay is independent of rec12+ and checkpoi...

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