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TP53 BRCA1 CRISPR single-cell cancer

Kuppu(Sundaram),Tan(Ek Han),Nguyen(Hanh),Rod… PLoS Genet 2016-05-31

The centromeric histone 3 variant (CENH3, aka CENP-A) is essential for the segregation of sister chromatids during mitos...

Bennett(Ailsa),Bechi(Beatrice),Tighe(Anthony… Oncotarget 2016-06-13

Aneuploidy is a common feature of cancer, with human solid tumour cells typically harbouring abnormal chromosome complem...

Maton(Gilliane),Edwards(Frances),Lacroix(Ben… Nat Cell Biol 2015-07-09

A critical structure poised to coordinate chromosome segregation with division plane specification is the central spindl...

Tomoshige(Koichi),Matsumoto(Keitaro),Tsuchiy… J Hum Genet 2016-09-30

Genetic factors are important in lung cancer, but as most lung cancers are sporadic, little is known about inherited gen...

Vertegaal(Alfred C O) Biochem Soc Trans 2010-03-15

Ubiquitin and ubiquitin-like proteins are conjugated to a wide variety of target proteins that play roles in all biologi...

Anton(Tobias),Bultmann(Sebastian),Leonhardt(… Nucleus 2015-01-22

Labeling and tracing of specific sequences in living cells has been a major challenge in studying the spatiotemporal dyn...

Caro Pérez(Alejandro),Kumble(Sarita),Kumble(… Autoimmune Dis 2014-02-14

The performance of immunoassays for the detection of autoantibodies is of critical importance in the diagnosis and asses...

DeRycke(Melissa S),Gunawardena(Shanaka R),Mi… Cancer Epidemiol Biomarkers P… 2013-11-06

Colorectal cancer (CRC) in densely affected families without Lynch Syndrome may be due to mutations in undiscovered gene...

Akiyoshi(Bungo),Nelson(Christian R),Duggan(N… PLoS Genet 2013-06-13

The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of du...

Wang(H),Hu(X),Ding(X),Dou(Z),Yang(Z),Shaw(AW… J Biol Chem 2004-12-24

Chromosome segregation in mitosis is orchestrated by dynamic interaction between spindle microtubules and the kinetochor...

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