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Structural investigation of nucleophosmin interaction with the tumor suppressor…

Di Matteo(A),Franceschini(M),Paiardini(A),Gr… Oncogenesis 2017-09-18

Nucleophosmin (NPM1) is a multifunctional nucleolar protein implicated in ribogenesis, centrosome duplication, cell cycl...

The Chaperone NASP Contributes to de Novo Deposition of the Centromeric Histone…

Takeuchi(H),Nagahara(S),Higashiyama(T),Berge… Plant Cell Physiol 2024-07-30

The centromere is an essential chromosome region where the kinetochore is formed to control equal chromosome distributio...

The variation and evolution of complete human centromeres.

Logsdon(GA),Rozanski(AN),Ryabov(F),Potapova(… Nature 2024-05-00

Human centromeres have been traditionally very difficult to sequence and assemble owing to their repetitive nature and l...

Correlation study between clinical phenotypes and autoantibodies in systemic sc…

Sui(J),Li(H),Liu(Y),Chen(Z),Chen(D),Mo(C),Hu… Medicine (Baltimore) 2025-06-06

This study investigates the characteristics of baseline data and the correlation between autoantibodies and clinical phe...

Mitotic antipairing of homologous and sex chromosomes via spatial restriction o…

Hua(LL),Mikawa(T) Proc Natl Acad Sci U S A 2018-00-26

Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental c...

Whole-genome sequencing in a family with twin boys with autism and intellectual…

McKenna(B),Koomar(T),Vervier(K),Kremsreiter(… Cold Spring Harb Mol Case Stud 2018-00-00

Over the past decade, a focus on de novo mutations has rapidly accelerated gene discovery in autism spectrum disorder (A...

Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Ca…

Kouprina(N),Petrov(N),Molina(O),Liskovykh(M)… ACS Synth Biol 2018-00-21

Since their description in the late 1990s, Human Artificial Chromosomes (HACs) bearing functional kinetochores have been...

Fabrication of polydopamine-altered PCL/PLGA nanofibrous scaffolds on cerium to…

Luo(C),Kang(C),Qiu(S),Wang(W),Lou(Y),Wang(X)… Biochem Biophys Res Commun 2025-00-20

...CeNPs), applying a polydopamine coating, and clacking with collagen. The mechanical tests and scanning electron microsco...

Total whole-arm chromosome losses predict malignancy in human cancer.

Zheng(Y),Ahmad(K),Henikoff(S) Proc Natl Acad Sci U S A 2025-05-06

Aneuploidy is observed as gains or losses of whole chromosomes or chromosome arms and is a common hallmark of cancer. Wh...

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy…

Stumme-Diers(MP),Stormberg(T),Sun(Z),Lyubche… J Vis Exp 2019-00-31

Chromatin, which is a long chain of nucleosome subunits, is a dynamic system that allows for such critical processes as ...

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