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Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes…

Jansen(Jacob G),Langerak(Petra),Tsaalbi-Shty… J Exp Med 2006-04-03

...Rev1 in mammalian somatic hypermutation we have generated mice deficient for Rev1. Although Rev1-/- mice display transie...

[Eukaryotic error prone DNA polymerases: suggested roles in replication, repair…

Krutiakov(V M) Mol Biol (Mosk) 2006-04-21

...Rev1. Their principal properties are described in this review. All of the polymerases under study are deprived of the co...

REV3 and REV1 play major roles in recombination-independent repair of DNA inter…

Shen(Xi),Jun(Sohee),O'Neal(Lindsey E),Sonoda… J Biol Chem 2006-07-21

...REV1 deletion mutant also revealed a significant reduction in recombination-independent ICL repair, suggesting that Rev1...

Ubiquitinated proliferating cell nuclear antigen activates translesion DNA poly…

Garg(Parie),Burgers(Peter M) Proc Natl Acad Sci U S A 2006-01-31

...Rev1, a deoxycytidyl transferase that functions in organizing the mutagenic DNA replication machinery. We propose that u...

Human REV1 modulates the cytotoxicity and mutagenicity of cisplatin in human ov…

Lin(Xinjian),Okuda(Tsuyoshi),Trang(Julie),Ho… Mol Pharmacol 2006-06-26

...REV1 expression vector and 4 sublines developed in which the hREV1 mRNA level was increased by 6.3- to 23.4-fold and hRE...

The catalytic activity of REV1 is employed during immunoglobulin gene diversifi…

Ross(Anna-Laura),Sale(Julian E) Mol Immunol 2006-05-22

...REV1. This provides the first clear evidence that the catalytic activity of REV1 is utilised in vivo in higher eukaryote...

Epistatic participation of REV1 and REV3 in the formation of UV-induced framesh…

Heidenreich(Erich),Eisler(Herfried),Steinboe… Mutat Res 2006-03-28

...Rev1p (REV1). In a NER-deficient strain background, the increased incidence of stationary-phase mutations was only moder...

The p-benzoquinone DNA adducts derived from benzene are highly mutagenic.

Xie(Zhongwen),Zhang(Yangbin),Guliaev(Anton B… DNA Repair (Amst) 2006-02-03

...REV1 and Polkappa were essentially incapable of translesion synthesis in response to the pBQ adducts. Opposite pBQ-dA an...

REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast.

Poltoratsky(Vladimir),Horton(Julie K),Prasad… DNA Repair (Amst) 2006-01-04

...REV1. The steady-state level of REV1 protein was reduced by more than 95% using stable expression of a siRNA construct i...

Ubiquitin-binding motifs in REV1 protein are required for its role in the toler…

Guo(Caixia),Tang(Tie-Shan),Bienko(Marzena),P… Mol Cell Biol 2006-12-26

...REV1 can physically interact with ubiquitin. The association of REV1 with ubiquitin requires the ubiquitin-binding motif...

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