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Substrate sequence influences γ-secretase modulator activity, role of the trans…

Sagi(SA),Lessard(CB),Winden(KD),Maruyama(H),… J Biol Chem 2011-11-18

...APLP2 retained the sensitivity to γ-cleavage modulation, but replacing TMDs from Notch-1 or ErbB4 rendered the resultant...

γ-Secretase-mediated regulation of neprilysin: influence of cell density and ag…

Bauer(C),Pardossi-Piquard(R),Dunys(J),Roy(M)… J Alzheimers Dis 2011-00-00

...APLP2, thereby confirming that Imatinib-mediated control of NEP could indeed be accounted for its effect on AICD.

Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectod…

Nitsch(RM),Deng(M),Growdon(JH),Wurtman(RJ) J Biol Chem 1996-02-23

...APLP2 ectodomain, suggesting that additional members of the APP multigene family are processed via similar regulated pat...

Beta-amyloid precursor protein (APP) and APP-RNA are rapidly affected by glutam…

Willoughby(DA),Rozovsky(I),Lo(AC),Finch(CE) J Mol Neurosci 1995-00-00

...APLP2) were not changed by Glu treatment. Our data are consistent with the hypothesis that sustained NMDA-receptor activ...

The FE65 proteins and Alzheimer's disease.

McLoughlin(DM),Miller(CC) J Neurosci Res 2008-03-00

...APLP2 knockout mice and also lissencephalopathies in humans. Thus APPs, FE65s, and mena may act together in a developmen...

Cell type and culture condition-dependent alternative splicing in human breast …

Li(C),Kato(M),Shiue(L),Shively(JE),Ares(M),L… Cancer Res 2006-02-15

...APLP2, and MYL6, were detected by the microarray and verified by reverse transcription-PCR. We also compared splicing in...

Expression and characterization of the human YWK-II gene, encoding a sperm memb…

Huang(P),Miao(S),Fan(H),Sheng(Q),Yan(Y),Wang… Mol Hum Reprod 2000-12-00

...APLP2/APPH. The YWK-II gene was mapped and assigned to human chromosome locus: 11q24-25. Northern blotting of various hu...

Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfac…

Cowan(CM),Thai(J),Krajewski(S),Reed(JC),Nich… J Neurosci 2001-09-15

...APLP2) as a caspase substrate that is cleaved in an identical spatiotemporal pattern, suggesting its cleavage is the res...

Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.

Homayouni(R),Rice(DS),Sheldon(M),Curran(T) J Neurosci 1999-09-01

...APLP2 in biochemical association experiments. In transiently transfected cells, Dab1 and APLP1 colocalized in membrane r...

Identification of proteins released by pancreatic cancer cells by multidimensio…

Mauri(P),Scarpa(A),Nascimbeni(AC),Benazzi(L)… FASEB J 2005-07-00

...APLP2, cyclophilin B, beta2 microglobulin, and ICA69. Evidence that cancer cells release these proteins in vivo was obta...

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