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Telomere elongation facilitated by trichostatin a in cloned embryos and pigs by…

Kong(Qingran),Ji(Guangzhen),Xie(Bingteng),Li… Stem Cell Rev 2014-12-18

...Rad50 and BLM show increased expression in TSA-treated embryos. These data suggest that TSA may promote telomere elongat...

DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-…

Zhou(Yi),Paull(Tanya T) J Biol Chem 2014-02-21

...Rad50-Nbs1 (MRN) complex further stimulates resection in the presence of Ku and DNA-PKcs by recruiting Exo1 and enhancin...

Genome-wide RNAi high-throughput screen identifies proteins necessary for the A…

Solaimani(Parrisa),Damoiseaux(Robert),Hankin… Toxicol Sci 2014-07-01

...RAD50 are required for the expression of AHR as well as for induction of CYP1A1. We also found 2 gene products, ARMC8 an...

Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate ho…

McKerlie(Megan),Walker(John R),Mitchell(Tayl… Nucleic Acids Res 2014-02-13

...Rad50/Nbs1-mediated DNA damage response. While loss of functional BRCA1 impairs the formation of IR-induced (pT371)TRF1 ...

Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice.

Leung(Thomas H),Zhang(Lillian F),Wang(Jing),… J Clin Invest 2014-02-04

...Rad50. Additionally, skin of aged HOCl-treated mice acquired enhanced epidermal thickness and proliferation, comparable ...

Aberrant DNA methylation status of DNA repair genes in breast cancer treated wi…

Watanabe(Yoshiyuki),Maeda(Ichiro),Oikawa(Rit… Genes Cells 2014-08-18

...RAD50, RAD51, RAD51C, MRE11, NBS1, CtIP and ATM. Among the genes analyzed, only the incidence of BRCA1 and RNF8 methylat...

Structural basis for DNA recognition and nuclease processing by the Mre11 homol…

Liu(Shun),Tian(Li-fei),Liu(Yan-ping),An(Xiao… Acta Crystallogr D Biol Cryst… 2014-10-21

...Rad50 and Nijmegen breakage syndrome 1 (Nbs1) plays multiple important roles in the sensing, processing and repair of DN...

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.

Roset(Ramon),Inagaki(Akiko),Hohl(Marcel),Bre… Genes Dev 2014-04-21

...Rad50(46/46) mutations were lethal in mice. However, in the presence of wild-type Rad50, Rad50(46) exerted a dominant ga...

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response t…

Wang(Qinhong),Goldstein(Michael),Alexander(P… EMBO J 2014-06-03

...RAD50-NBS1 (MRN) complex is essential for the detection of DNA double-strand breaks (DSBs) and initiation of DNA damage ...

[Radiobiological characteristics and MRN complex expression of human nasopharyn…

Huang(Jian-cong),Zhang(Ge-hua),Li(Jing-jia),… Zhonghua Er Bi Yan Hou Tou Ji… 2014-03-10

...Rad50 in CNE1 and Mre11, Rad50 and Nbs1 in CNE2 (P < 0.05).,CNE1 and CNE2 were sensitive to radiation, but there were ra...

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