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Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific doma…

Wang(Jian-Qiu),Chen(Jian-Hong),Chen(Yen-Chun… PLoS One 2014-01-14

...Rad50-NBS1 complex. SIN1 is a component of the mTOR/Rictor/SIN1 complex mediating the activation of Akt. Here we show th...

The generation of oxidative stress-induced rearrangements in Saccharomyces cere…

Dzierzbicki(Piotr),Kaniak-Golik(Aneta),Malc(… Mutat Res 2014-05-05

...RAD50 or XRS2 gene, both encoding the components of the MRX complex, which is known to be involved in the repair of doub...

Synergistic anticancer activity of arsenic trioxide with erlotinib is based on …

Kryeziu(Kushtrim),Jungwirth(Ute),Hoda(Mir Al… Mol Cancer Ther 2014-02-24

...Rad50 as well as reduced phosphorylation of BRCA1. Finally, the combination treatment of ATO and erlotinib was also dist...

A multistep genomic screen identifies new genes required for repair of DNA doub…

McKinney(Jennifer Summers),Sethi(Sunaina),Tr… BMC Genomics 2014-01-09

...RAD50, RAD51, RAD52, RAD54, RAD55, RAD57, MRE11 and XRS2) and 73 additional genes were found to be required for efficien...

DNA replication and homologous recombination factors: acting together to mainta…

Aze(Antoine),Zhou(Jin Chuan),Costa(Alessandr… Chromosoma 2014-03-26

...Rad50-Nbs1 complex, are required to ensure complete and faithful replication. Consistent with this notion, many of the g...

Copy neutral loss of heterozygosity is more frequent in older ovarian cancer pa…

Pedersen(Brent S),Konstantinopoulos(Panagiot… Genes Chromosomes Cancer 2014-01-03

...RAD50, RAD52, XRCC2, XRCC3, and MRE11A in these patient samples. Furthermore, we develop a metric for pathway-level imba...

c-Myc quadruplex-forming sequence Pu-27 induces extensive damage in both telome…

Islam(Md Ashraful),Thomas(Shelia D),Murty(Vu… J Biol Chem 2014-05-27

...RAD50), double-stranded break repair molecule 53BP1, G2 checkpoint regulators (CHK1 and CHK2), and anti-apoptosis gene s...

Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.

Schröder-Heurich(Bianca),Wieland(Britta),Lav… FASEB J 2014-05-01

...RAD50-proficient fibroblasts but not in RAD50-deficient cells. Cells with a RAD50-positive chromatin bridge were able to...

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

Roth(Susanne),Rottach(Andrea),Lotz-Havla(Ame… Nat Immunol 2014-07-28

...Rad50 and the innate immune system adaptor CARD9. Transfection of dendritic cells with dsDNA or infection of dendritic c...

Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down…

Martins(Célia),Doran(Carolina),Silva(Inês C)… Chem Biol Interact 2014-09-02

...RAD50, RAD51) and DNA damage signalling (ATM) and stress response (GADD45A, GADD45G). On the whole, we demonstrate that ...

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