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CtIP maintains stability at common fragile sites and inverted repeats by end re…

Wang(Hailong),Li(Yongjiang),Truong(Lan N),Sh… Mol Cell 2014-09-02

...Rad50/Nbs1 complex (MRN). We also identified an endonuclease activity of CtIP that is dispensable for end resection and ...

DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA e…

Sturzenegger(Andreas),Burdova(Kamila),Kanaga… J Biol Chem 2014-12-11

...Rad50-Xrs2 complex and Sae2, the extension of resection tracts is mediated either by exonuclease 1 or by combined activi...

Catalytic mechanism of bacteriophage T4 Rad50 ATP hydrolysis.

Herdendorf(Timothy J),Nelson(Scott W) Biochemistry 2014-11-21

...Rad50 proteins, a nuclease and an ATPase, respectively, form a well-conserved complex that is involved in the initial pr...

UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induce…

Zhang(Tianyi),Cronshaw(Janet),Kanu(Nnennaya)… Proc Natl Acad Sci U S A 2014-11-03

...Rad50/NBS1 (MRN) protein complex and ATMIN protein mediate ATM kinase signaling in response to ionizing radiation (IR) a...

Relevance of telomere/telomerase system impairment in early stage chronic lymph…

Hoxha(Mirjam),Fabris(Sonia),Agnelli(Luca),Bo… Genes Chromosomes Cancer 2014-12-04

...RAD50, and RPA1 transcript levels was observed in CLLs compared with controls. Our study suggests that impairment of tel...

Highly heterogeneous, activated, and short-lived regulatory T cells during chro…

Metenou(Simon),Coulibaly(Yaya I),Sturdevant(… Eur J Immunol 2014-09-10

...RAD50, TNFRSF1A, FOXO3, and RHOA were significantly upregulated in stimulated cells compared with unstimulated cells. Ta...

Hereditary breast and ovarian cancer: assessment of point mutations and copy nu…

Silva(Felipe C),Lisboa(Bianca Cg),Figueiredo… BMC Med Genet 2014-08-04

...RAD50, RAD51, BRIP1, PALB2, MLH1, MSH2, MSH6, TP53, CDKN2A, CDH1 and CTNNB1).,Capillary sequencing and multiplex ligatio...

Productive replication of human papillomavirus 31 requires DNA repair factor Nb…

Anacker(Daniel C),Gautam(Dipendra),Gillespie… J Virol 2014-10-01

...Rad50-Nbs1 (MRN) complex is an essential component of the DDR that is necessary for ATM-mediated HR repair and localizes...

SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple prot…

Wu(Ching-Shyi),Ouyang(Jian),Mori(Eiichiro),N… Genes Dev 2014-09-02

...RAD50-NBS1 complex, exhibit reduced binding to the ATRIP SUMOylation mutant in cells and display affinity for SUMO2 chai...

Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation …

Chen(Chen),Zhang(Liguo),Huang(Nai-Jia),Huang… Proc Natl Acad Sci U S A 2014-02-24

...Rad50/Nijmegen breakage syndrome 1 proteins] to sites of DNA damage where ATM phosphorylates multiple substrates to trig...

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