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Assembly of the Human Multi-tRNA Synthetase Complex Through Leucine Zipper Moti…

Kim(DK),Lee(K),Kang(BS) J Mol Biol 2024-12-15

...AIMP2 is still ambiguous since AIMP2 is known to not only bind to AIMP1 but also form a homodimer through its LZ. Here, ...

Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protei…

Shin(JY),Ha(MW),Kim(JH),Cheon(J),Lee(GH),Pae… iScience 2024-11-15

Aminoacyl-tRNA synthetase interacting multifunctional protein-2 (AIMP2), a parkin substrate, possesses self-aggregating ...

The Allelic Expression of RNA Editing Gene ADARB1 in Hepatocellular Carcinoma T…

Zeng(J),Han(L),Wang(T),Huang(L),Zheng(Y),Zha… Pharmgenomics Pers Med 2023-00-00

...AIMP2) in two independent TACE patient cohorts. We found that ADARB1 rs1051367 and rs2253763 polymorphisms were markedly...

Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal C…

Kook(MG),Byun(MR),Lee(SM),Lee(MH),Lee(DH),Le… Mol Neurobiol 2023-01-00

...AIMP2 from its original binding partner KARS1, and the free form of AIMP2 induced TRAF2 degradation followed by TNF-α-in...

Synthesis and discovery of the first potent proteolysis targeting chimaera (PRO…

Lee(B),Kim(DG),Lee(A),Kim(YM),Cui(L),Kim(S),… J Enzyme Inhib Med Chem 2023-12-00

...AIMP2) is known to be a powerful tumour suppressor. However, the target AIMP2-DX2, AIMP2-lacking exon 2, is often detect...

The allelic regulation of tumor suppressor ADARB2 in papillary thyroid carcinom…

Li(W),Wang(T),Fu(G),Xu(Y),Zhang(N),Han(L),Ya… Endocr Relat Cancer 2023-00-01

...AIMP2 in PTC. We identified ADARB2 rs904957 and rs1007147 genetic variants which are associated with significantly eleva...

Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer.

Qiu(J),Zhou(T),Wang(D),Hong(W),Qian(D),Meng(… Curr Genomics 2023-12-20

...AIMP2 on tumor immune cell infiltration, proliferation, and migration remain unclear. To assess AIMP2's role in tumor im...

Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting …

Zheng(Y),Zhan(Y),Zhang(Y),Zhang(Y),Liu(Y),Xi… Cell Death Dis 2023-00-01

...AIMP2) while enhancing its autophagic lysosomal-dependent degradation, thereby increasing radio-resistance of HCC. Pharm...

Identification and evaluation of midbrain specific longevity-related genes in e…

Kim(H),Huh(YJ),Kim(JH),Jo(M),Shin(JH),Park(S… Front Aging Neurosci 2022-00-00

...aimp2, hexb, cacybp, akt2, nrf1, axin1, wwp2, sp2, dnajb9, notch, traf7, and lrp1. A detailed biochemical analysis of th...

Case Report: Mutation in AIMP2/P38, the Scaffold for the Multi-Trna Synthetase …

Mazaheri(M),Yavari(M),Zare Marzouni(H),Stufa… Front Genet 2022-00-00

...AIMP2 mutation. This finding broadens the mutational and phenotypic spectra of AIMP2-related leukodystrophy and offers g...

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