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Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploi...

Xu(Y),Loucks(H),Menendez(J),Ryabov(F),Luca... Cell Genom 2026-08-12

Centromeres ensure chromosome segregation, but their chromatin organization within repetitive alpha-satellite DNA has be...

Phased T2T horse and donkey assemblies from a mule reveal peculiar equid cent...

Li(K),Cappelletti(E),Dessaix(C),Ciosek(J),... Cell Genom 2026-08-12

We present telomere-to-telomere genome assemblies of a Thoroughbred horse and a donkey derived from their mule offspring...

Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A dr...

Mahlke(MA),Enriquez(A),Lumerman(L),Nath(P)... Cell Rep 2026-08-05

Centromere identity is specified by CENP-A, a histone H3 variant that epigenetically defines centromere position. How CE...

Integrated Mendelian Randomization and Single-Cell Transcriptomics Reveal T C...

Zhang(D),Ren(H),Bai(Y),Han(P) Life (Basel) 2026-08-21

Objective: Patients with systemic lupus erythematosus (SLE) exhibit elevated malignancy risk, with increased bladder can...

Condensation of MATCAP promotes CENP-E-dependent chromosome congression in mi...

Yang(T),Hu(W),Xu(P),Li(H),Zhang(Y),Xiong(F... Nat Commun 2026-07-30

Accurate segregation of mitotic chromosomes requires pre-anaphase alignment driven by microtubule-based motor proteins. ...

Retention of a single Cenp-C gene in different syntenic locations in the mont...

Soares(RF),Chang(CH),Koerich(LB),Malik(HS)... Heredity (Edinb) 2026-09-11

Chromosome segregation in eukaryotes requires the orchestrated interaction of chromosomes with microtubules, mediated by...

Epigenetic landscape of synthetic human centromere core regions: CENP-A assem...

Ohzeki(J),Watanabe(A),Lee(JX),Minami(C),Ku... Nucleic Acids Res 2026-06-22

Centromeres are specialized chromatin structures essential for equal chromosome segregation. The human centromeres are o...

CENP-A in cancer: from centromere identity to genome instability.

Yildirim(IG),Biterge(B) Mol Biol Rep 2026-06-09

Chromatin organization plays a fundamental role in the regulation and preservation of the eukaryotic genome. Histone var...

Non-centromeric CENP-A regulates epithelial-mesenchymal plasticity and hetero...

Renaud-Pageot(C),Capocefalo(D),Lemaire(S),... Cell Rep 2026-06-23

Centromere protein A (CENP-A), a centromeric histone H3 variant highly expressed in aggressive cancers, promotes epithel...

CENP-B: Cornerstone of Kinetochores in Centromeres of Human Chromosomes.

Parl(FF) Front Biosci (Landmark Ed) 2026-05-18

Each chromosome contains a centromere, the site at which the kinetochore assembles to ensure accurate chromosome segrega...

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