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Translesion Synthesis DNA Polymerase Gene Expression Is Impacted by Age and IGF…

Rider(SD),Owens(MS),Rohan(CA),Travers(JB),Ke… JID Innov 2025-11-00

...REV1, and REV7 were found to be inversely correlated with the skin aging biomarker gene COL1A1 but not with S100A7 among...

Translesion polymerases and DNA-protein crosslink repair shapes the cellular re…

Blouin(T),Ampolini(E),Stayer(K),Suresh(P),Mi… Nucleic Acids Res 2025-09-05

...Rev1 and Pol η function together to prevent FA mutagenesis. Overall, these results outline the mechanisms by which TLS a...

Translesion DNA polymerases Rev1 and PolH promote LTR-retrotransposon transcrip…

Li(C),Meng(Z),Wen(Q),Yang(W),Xu(Y),Lyu(Y),Gu… Nucleic Acids Res 2025-09-05

...Rev1 and PolH, as positive regulators of transposons. Rev1 and PolH are interacting partners. Our CUT&Tag data show that...

WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-famil…

Yoon(JH),Sellamuthu(K),Prakash(L),Prakash(S) Elife 2025-09-03

...Rev1 in TLS. Among these proteins, WRN possesses a 3'→5' exonuclease activity and an ATPase/3'→5' DNA helicase activity,...

REV1 inhibition enhances trinucleotide repeat mutagenesis.

Siegel(A),Almstead(D),Kothandaraman(N),Reich… bioRxiv 2025-09-16

...REV1 by its inhibitor, JH-RE-06, or siRNA knockdown increases TNR instability and the underlying mutability. These resul...

Sensitization of cancer cells to DNA-damaging agents by expression of the REV1 …

Bian(K),Gruber(CC),Byers(E),Leclerc(P),Heman… Proc Natl Acad Sci U S A 2025-09-16

...REV1, a ca. 100 amino acid scaffold essential for TLS polymerase interactions, disrupts REV1/POLζ-dependent TLS in mamma...

DNA polymerase kappa is the primary translesion synthesis polymerase for aldehy…

van der Sluijs(RV),Verkennis(AEE),Hodskinson… Nucleic Acids Res 2025-09-23

...Rev1 interaction. In contrast, Polκ has a non-catalytic role in the extension step of cisplatin ICL repair that is depen...

Identification of a PCNA-binding motif in human translesion DNA polymerase REV1…

Hishiki(A),Hoshino(N),Okawara(K),Fuchigami(S… J Biochem 2025-11-04

...REV1 and PCNA also remains unclear. Here, we identified a signature sequence conserved within vertebrates REV1 responsib...

The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regul…

Uchiyama(Masashi),Terunuma(Junko),Hanaoka(Fu… PLoS One 2016-03-30

...Rev1 protein levels. Besides these effects during the cell cycle, we also observed upregulation of Rev1 protein upon DNA...

The steady-state level and stability of TLS polymerase eta are cell cycle depen…

Plachta(Michal),Halas(Agnieszka),McIntyre(Ju… DNA Repair (Amst) 2016-02-08

...Rev1, indicate that cell cycle regulation is a general property of Y family TLS polymerases in S. cerevisiae.

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