...TP53 (HR, 1.55; 95% CI, 1.38-1.73). TMB of ≥20 mutations/Mb and 2 DNA mismatch repair signatures (SBS6 and SBS26) associ...
...TP53 mutation. Composite complete response rates were higher with LIT + VEN compared to LIT (58% vs. 40%, P = 0.003) but...
...TP53, AKT1, STAT3, MYC, RELA, EP300, CREBBP, JUN, HSP90AA1, and MAPK3 as central nodes. Enrichment analyses implicated F...
...TP53. Clinical data has verified that the upregulation of key components of this pathway (TP53, MDM2, MDM4, and cyclin-d...
...TP53 c.811G>A p. (Glu271Lys) (VAF 0.90). Targeted panel sequencing showed no other actionable mutations. MSI readout was...
...TP53. Molecular docking and dynamics simulations demonstrated stable binding of KLM-derived flavonoids with BCRP, MRP1, ...
...TP53, and AKT1. GO and KEGG analyses reveal that the mechanisms primarily involve the regulation of apoptotic signaling ...
...TP53 and portending worse survival. Recent developments have expanded the spectrum of squamous intraepithelial lesions (...
...TP53 codon 72 (Arg/Pro), DNA repair and metabolic genes (XRCC1, MTHFR), and detoxification gene null genotypes (GSTM1, G...
...TP53 (1.4%). VUS and benign/VUS variants were detected in 4.6% (30/647) and 3.1% (20/647) of individuals, respectively. ...
山东省济南市章丘区文博路2号
齐鲁师范学院 genelibs生信实验室
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