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The essential function of the MRN complex in the resolution of endogenous repli…

Bruhn(Christopher),Zhou(Zhong-Wei),Ai(Haiyan… Cell Rep 2014-09-25

...Rad50/Nbs1) is important in double-strand break (DSB) recognition, end resection, replication fork stabilization, and AT...

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM c…

Deshpande(Rajashree A),Williams(Gareth J),Li… EMBO J 2014-04-25

...Rad50 complex is highly conserved, yet the mechanisms by which Rad50 ATP-driven states regulate the sensing, processing ...

Organization and maintenance of Drosophila telomeres: the roles of terminin and…

Raffa(G D),Cenci(G),Ciapponi(L),Gatti(M) Tsitologiia 2013-07-12

...Rad50-Nbs (MRN) complex, and the Woc transcription factor. The terminin proteins are encoded by fast-evolving genes and ...

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differentia…

Cheng(Yun-Hsin),Chuang(Chi-Ning),Shen(Hui-Ju… Mol Cell Biol 2013-10-23

...Rad50-Xrs2 complex. During SC assembly, Zip1 outcompetes 9-1-1 from the Red1-SUMO chain ensemble to attenuate Hop1 phosp...

Analysis of the effect of radiation repair mutations on the DEL1 mutator region…

Downs(K M),Szwast(A E),Liebman(S W) Curr Genet 2013-11-01

...rad50-1, and rad51-1, toDEL1 and asked whether DEL1 was still functional. We found that none of these rad mutations sign...

Isolation and characterization of yeast DNA repair genes : II. Isolation of pla…

Calderon(I L),Contopoulou(C R),Mortimer(R K) Curr Genet 2013-11-01

...rad50-1 complementing plasmid failed to integrate at the RAD50 locus, indicating that no homology exists between this fr...

Nucleolin mediates nucleosome disruption critical for DNA double-strand break r…

Goldstein(Michael),Derheimer(Frederick A),Ta… Proc Natl Acad Sci U S A 2013-12-09

...RAD50 via its arginine-glycine rich domain and is recruited to DSBs rapidly in an MRE11-NBS1-RAD50 complex-dependent man...

Enhanced levels of double-strand DNA break repair proteins protect ovarian canc…

Kalra(Rajkumar Singh),Bapat(Sharmila A) J Ovarian Res 2013-11-15

...RAD50, NPM1, and XRCC5 in transformed cells over pre-transformed, non-tumorigenic cells. Analysis of the functional rele...

Competition between NBS1 and ATMIN controls ATM signaling pathway choice.

Zhang(Tianyi),Penicud(Kay),Bruhn(Christopher… Cell Rep 2013-06-07

...Rad50-NBS1 (MRN) complex, whereas ATM interactor (ATMIN) protein is required for ATM signaling induced by changes in chr...

Estrus synchronization and ovarian hyper-stimulation treatments have negligible…

Agca(Cansu),Yakan(Akin),Agca(Yuksel) Mol Reprod Dev 2013-07-30

...Rad50, and Mcm6); reproductive developmental process; and granulosa cell expansion (Gdf9, Bmp15, Amh, Amhr2, Bmpr1b, Tgf...

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