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Short hairpin RNA-mediated down-regulation of CENP-A attenuates the aggressiv...

Wu(Qing),Chen(Yong-Feng),Fu(Jie),You(Qi-Ha... Cell Oncol (Dordr) 2015-09-15

Deregulation of centromere protein (CENP)-A, a centromere-specific histone variant, has in the past been linked to cance...

Replication of alpha-satellite DNA arrays in endogenous human centromeric reg...

Erliandri(Indri),Fu(Haiqing),Nakano(Megumi... Nucleic Acids Res 2015-01-15

In human chromosomes, centromeric regions comprise megabase-size arrays of 171 bp alpha-satellite DNA monomers. The larg...

Serological profile of patients with systemic sclerosis.

Wielosz(Ewa),Dryglewska(Magdalena),Majdan(... Postepy Hig Med Dosw (Onlin... 2015-06-26

The systemic sclerosis-associated autoantibodies include anti-centromere, anti-topoisomerase I (anti-topo I), anti-RNA p...

Centromeric heterochromatin: the primordial segregation machine.

Bloom(Kerry S) Annu Rev Genet 2015-07-08

Centromeres are specialized domains of heterochromatin that provide the foundation for the kinetochore. Centromeric hete...

HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trim...

Mukai(Risa),Ohshima(Takayuki) J Gen Virol 2015-03-30

Human T-cell leukaemia virus type-1 (HTLV-1) infection causes adult T-cell leukaemia (ATL). The viral protein HTLV-1 bZI...

Ectopic centromere nucleation by CENP--a in fission yeast.

Gonzalez(Marlyn),He(Haijin),Dong(Qianhua),... Genetics 2015-07-23

The centromere is a specific chromosomal locus that organizes the assembly of the kinetochore. It plays a fundamental ro...

The protective role of antifreeze protein 3 on the structure and function of ...

Wen(Yan),Zhao(Shuqin),Chao(Lan),Yu(Honglin... Cryobiology 2015-05-18

Several studies have reported the oocyte damage in mice during vitrification; however, little has been known about the p...

Prognostic relevance and therapeutic implications of centromere protein F exp...

Mi(Y-J),Gao(J),Xie(J-D),Cao(J-Y),Cui(S-X),... Dis Esophagus 2014-03-26

Centromere protein F (CENP-F), a cell cycle-regulated centromere protein, has been shown to affect numerous tumorigenic ...

Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.E...

Hirayama(Takaharu),Okaniwa(Masanori),Imada... Bioorg Med Chem 2014-03-18

Centromere-associated protein-E (CENP-E), a mitotic kinesin that plays an important role in mitotic progression, is an a...

Mitosis as an anti-cancer drug target.

Salmela(Anna-Leena),Kallio(Marko J) Chromosoma 2014-03-26

Suppression of cell proliferation by targeting mitosis is one potential cancer intervention. A number of existing chemot...

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