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DNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archa…

Delmas(Stéphane),Duggin(Iain G),Allers(Thors… Mol Microbiol 2013-07-02

...Rad50 complex, suggesting a link to DNA double-strand break repair. However, compaction was observed in a radA mutant, i...

The fission yeast MRN complex tethers dysfunctional telomeres for NHEJ repair.

Reis(Clara Correia),Batista(Sílvia),Ferreira… EMBO J 2013-02-06

...Rad50-Nbs1) complex prevents NHEJ at telomeres and, as a result, rescues taz1Δ lethality in G1. Neither Tel1(ATM) activa...

MSH3-deficiency initiates EMAST without oncogenic transformation of human colon…

Campregher(Christoph),Schmid(Gerald),Ferk(Fr… PLoS One 2013-05-22

...RAD50), apoptosis, L1 recycling, and repression of proteins involved in metabolism, tRNA aminoacylation, and gene expres...

Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-indepe…

Conradt(Laura),Henrich(Annika),Wirth(Matthia… Int J Cancer 2013-04-26

...Rad50-Nijmegen breakage syndrome (Nbs) 1 DNA repair complex. In addition, we provide evidence that Mdm2 inhibitors delay...

Innate immunity and non-Hodgkin's lymphoma (NHL) related genes in a nested case…

Park(Sue K),Yang(Jae Jeong),Oh(Sohee),Cho(Li… PLoS One 2013-02-28

...RAD50, CASP7, CHUK, CD79B, and CLDN9) with a permutated p-value <0.01 were re-genotyped in the Replication phase among 3...

Global gene expression in Coprinopsis cinerea meiotic mutants reflects checkpoi…

Anderson(Erika),Burns(Claire),Zolan(Miriam E) G3 (Bethesda) 2013-03-17

...rad50-1, which arrests in late prophase, RNA abundance for a group of early meiotic genes remains high, whereas the expr...

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand…

Limbo(Oliver),Moiani(Davide),Kertokalio(Arya… Nucleic Acids Res 2013-02-22

The Mre11 complex (Mre11-Rad50-Nbs1 or MRN) binds double-strand breaks where it interacts with CtIP/Ctp1/Sae2 and ATM/Te...

Structural and functional characterization of an SMC-like protein RecN: new ins…

Pellegrino(Simone),Radzimanowski(Jens),de Sa… Structure 2013-05-17

...Rad50. An extensive high- and low-resolution structural analysis of Deinococcus radiodurans RecN using a combination of ...

RING finger nuclear factor RNF168 is important for defects in homologous recomb…

Muñoz(Meilen C),Laulier(Corentin),Gunn(Amand… J Biol Chem 2013-02-28

...RAD50, BRCA2, or RAD51. Furthermore, RNF168-depleted cells can form ionizing radiation-induced foci of the recombinase R...

MAIGO2 is involved in abscisic acid-mediated response to abiotic stresses and G…

Zhao(Pengshan),Liu(Fei),Zhang(Bo),Liu(Xin),W… Physiol Plant 2013-12-09

...Rad50-interacting protein, is found to be required for the responses to salt stress, osmotic stress and abscisic acid in...

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